ArticleNuclear medicine and biology2014
Gold nanorod-mediated hyperthermia enhances the efficacy of HPMA copolymer-90Y conjugates in treatment of prostate tumors.
Article in Nuclear medicine and biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Methods for Radiolabeling Nanoparticles (Part 3): Therapeutic Use.Biomolecules · 2023Pooled it
- Multi-functionalization of reduced graphene oxide nanosheets for tumor theragnosis: Synthesis, characterization, enzyme assay, in-silico study, radiolabeling and in vivo targeting evaluation.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Article
- Gold nanoparticles and gold nanorods in the landscape of cancer therapy.Molecular cancer · 2023Review
- Preparation, toxicity reduction and radiation therapy application of gold nanorods.Journal of nanobiotechnology · 2021Review
- Low-Temperature Photothermal Therapy: Strategies and Applications.Research (Washington, D.C.) · 2021Review
- Radiolabeled Gold Nanoparticles for Imaging and Therapy of Cancer.Materials (Basel, Switzerland) · 2020Review
- In Vitro Evaluation and Biodistribution Studies of HPMA Copolymers Targeting the Gastrin Releasing Peptide Receptor in Prostate Cancer.Pharmaceutical research · 2020Article
- Review of Therapeutic Applications of Radiolabeled Functional Nanomaterials.International journal of molecular sciences · 2019Review
- Alliance with EPR Effect: Combined Strategies to Improve the EPR Effect in the Tumor Microenvironment.Theranostics · 2019Review
- Comparative Endocytosis Mechanisms and Anticancer Effect of HPMA Copolymer- and PAMAM Dendrimer-MTCP Conjugates for Photodynamic Therapy.Macromolecular bioscience · 2017Article
- Rethinking cancer nanotheranostics.Nature reviews. Materials · 2017Article
- Radio-nanomaterials for biomedical applications: state of the art.European journal of nanomedicine · 2016Article
- An MRI-based classification scheme to predict passive access of 5 to 50-nm large nanoparticles to tumors.Scientific reports · 2016Article
- Comparative effect of gold nanorods and nanocages for prostate tumor hyperthermia.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- Polymer-Based Prodrugs: Improving Tumor Targeting and the Solubility of Small Molecule Drugs in Cancer Therapy.Molecules (Basel, Switzerland) · 2015Review
- Mild hyperthermia enhances transport of liposomal gemcitabine and improves in vivo therapeutic response.Advanced healthcare materials · 2015Article
- Nanoscale materials for hyperthermal theranostics.Nanoscale · 2015Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
introductionThe treatment of prostate cancer using a radiotherapeutic (90)Y labeled N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer can be enhanced with localized tumor hyperthermia. An (111)In labeled HPMA copolymer system for single photon emission computerized tomography (SPECT) was developed to observe the biodistribution changes associated with hyperthermia. Efficacy studies were conducted in prostate tumor bearing mice using the (90)Y HPMA copolymer with hyperthermia.
methodsHPMA copolymers containing 1, 4, 7, 10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) were synthesized by reversible addition-fragmentation transfer (RAFT) copolymerization and subsequently labeled with either (111)In for imaging or (90)Y for efficacy studies. Radiolabel stability was characterized in vitro with mouse serum. Imaging and efficacy studies were conducted in DU145 prostate tumor bearing mice. Imaging was performed using single photon emission computerized tomography (SPECT). Localized mild tumor hyperthermia was achieved by plasmonic photothermal therapy using gold nanorods.
resultsHPMA copolymer-DOTA conjugates demonstrated efficient labeling and stability for both radionuclides. Imaging analysis showed a marked increase of radiolabeled copolymer within the hyperthermia treated prostate tumors, with no significant accumulation in non-targeted tissues. The greatest reduction in tumor growth was observed in the hyperthermia treated tumors with (90)Y HPMA copolymer conjugates. Histological analysis confirmed treatment efficacy and safety.
conclusionHPMA copolymer-DOTA conjugates radiolabeled with both the imaging and treatment radioisotopes, when combined with hyperthermia can serve as an image guided approach for efficacious treatment of prostate tumors.
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