ArticleJournal of diabetes and its complications
Serum uric acid and insulin sensitivity in adolescents and adults with and without type 1 diabetes.
Article in Journal of diabetes and its complications. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02502071 (Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 DiabetesL a Open-label Trial), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 DiabetesL a Open-label Trial
Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Serum uric acid predicts vascular complications in adults with type 1 diabetes: the coronary artery calcification in type 1 diabetes study.Acta diabetologica · 2014Trial
- Cross-sectional study on the association between serum uric acid levels and non-alcoholic fatty liver disease in an elderly population.Scientific reports · 2025Article
- Excessive gluconeogenesis causes the hepatic insulin resistance paradox and its sequelae.Heliyon · 2022Review
- Association between circulating cystatin C and hyperuricemia: a cross-sectional study.Clinical rheumatology · 2022Article
- Alterations in Biomarkers Related to Glycemia, Lipid Metabolism, and Inflammation up to 20 Years Before Diagnosis of Type 1 Diabetes in Adults: Findings From the AMORIS Cohort.Diabetes care · 2022Article
- Converging Relationships of Obesity and Hyperuricemia with Special Reference to Metabolic Disorders and Plausible Therapeutic Implications.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Impaired myocardial deformation and ventricular vascular coupling in obese adolescents with dysglycemia.Cardiovascular diabetology · 2019Observational
- Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications.International journal of endocrinology · 2019Review
- Article
- Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review.Journal of advanced research · 2017Review
- Xanthine oxidase inhibition protects against Western diet-induced aortic stiffness and impaired vasorelaxation in female mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Testosterone concentration and insulin sensitivity in young men with type 1 and type 2 diabetes.Pediatric diabetes · 2016Article
- Fructose and uric acid in diabetic nephropathy.Diabetologia · 2015Review
- Diabetes Mellitus, Obesity, and Diagnosis of Amyotrophic Lateral Sclerosis: A Population-Based Study.JAMA neurology · 2015Article
- Sex differences in renal and metabolic responses to a high-fructose diet in mice.American journal of physiology. Renal physiology · 2015Article
- Insulin sensitivity and complications in type 1 diabetes: New insights.World journal of diabetes · 2015Review
- Estimated insulin sensitivity predicts regression of albuminuria in Type 1 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2015Observational
- Early diabetic nephropathy in type 1 diabetes: new insights.Current opinion in endocrinology, diabetes, and obesity · 2014Review
- Serum uric acid and hypertension in adults: a paradoxical relationship in type 1 diabetes.Journal of clinical hypertension (Greenwich, Conn.) · 2014Observational
- Association of uric acid with metabolic syndrome in men, premenopausal women and postmenopausal women.International journal of environmental research and public health · 2014Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
hypothesisDecreased insulin sensitivity (IS) exists in type 1 diabetes. Serum uric acid (SUA), whose concentration is related to renal clearance, predicts vascular complications in type 1 diabetes. SUA is also inversely associated with IS in non-diabetics, but has not been examined in type 1 diabetes. We hypothesized SUA would be associated with reduced IS in adolescents and adults with type 1 diabetes.
methodsThe cross-sectional and longitudinal associations of SUA with IS were investigated in 254 adolescents with type 1 diabetes and 70 without in the Determinants of Macrovascular Disease in Adolescents with Type 1 Diabetes Study, and in 471 adults with type 1 diabetes and 571 without in the Coronary Artery Calcification in Type 1 diabetes (CACTI) study.
resultsSUA was lower in subjects with type 1 diabetes (p<0.0001), but still remained inversely associated with IS after multivariable adjustments in adolescents (β±SE: -1.99±0.62, p=0.001, R2 =2%) and adults (β±SE: -0.91±0.33, p=0.006, R2 = 6%) with type 1 diabetes, though less strongly than in non-diabetic controls (adolescents: β±SE: -2.70±1.19, p=0.03, R2 = 15%, adults: β±SE: -5.99±0.75, p<0.0001, R2 =39%).
conclusionWe demonstrated a significantly weaker relationship between SUA and reduced IS in subjects with type 1 diabetes than non-diabetic controls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.