Evidence map›Paper›PMID 24461328›Full record

ArticleBiomaterials2014

Cell based metabolic barriers to glucose diffusion: macrophages and continuous glucose monitoring.

Ulrike Klueh, Jackman T Frailey, Yi Qiao, Omar Antar, Donald L Kreutzer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Tissue Response to Subcutaneous Infusion Catheter.Journal of diabetes science and technology · 2020
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Insulin Derived Fibrils Induce CytotoxicityJournal of diabetes science and technology · 2023
    Article
  6. Review
  7. Article
  8. HNanomaterials (Basel, Switzerland) · 2022
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Simultaneous spatiotemporal tracking and oxygen sensing of transient implants in vivo using hot-spot MRI and machine learning.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ulrike KluehCenter for Molecular Tissue Engineering, University of Connecticut, School of Medicine, Farmington, CT 06030, USA; Department of Surgery, University of Connecticut, School of Medicine, Farmington, CT 06030, USA. Electronic address: klueh@nso.uchc.edu.
Jackman T FraileyCenter for Molecular Tissue Engineering, University of Connecticut, School of Medicine, Farmington, CT 06030, USA; Department of Surgery, University of Connecticut, School of Medicine, Farmington, CT 06030, USA.
Yi QiaoCenter for Molecular Tissue Engineering, University of Connecticut, School of Medicine, Farmington, CT 06030, USA; Department of Surgery, University of Connecticut, School of Medicine, Farmington, CT 06030, USA.
Omar AntarCenter for Molecular Tissue Engineering, University of Connecticut, School of Medicine, Farmington, CT 06030, USA; Department of Surgery, University of Connecticut, School of Medicine, Farmington, CT 06030, USA.
Donald L KreutzerCenter for Molecular Tissue Engineering, University of Connecticut, School of Medicine, Farmington, CT 06030, USA; Department of Surgery, University of Connecticut, School of Medicine, Farmington, CT 06030, USA.
University of Connecticut · US

Funding

Macrophages and Biosensor Function in VivoR01DK081171 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KREUTZER, DON · 2009 to 2013
$2.3M
Impact of the Vascular System and CGMDP3DK101082 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KREUTZER, DON · 2013 to 2013
$1.8M
NIDDK NIH HHS DP3 DK101082NIDDK NIH HHS R01 DK081171
6 · The paper itself

Abstract

It is assumed that MQ are central to glucose sensor bio-fouling and therefore have a major negative impact on continuous glucose monitoring (CGM) performance in vivo. However to our knowledge there is no data in the literature to directly support or refute this assumption. Since glucose and oxygen (O2) are key to glucose sensor function in vivo, understanding and controlling glucose and O2 metabolic activity of MQ is likely key to successful glucose sensor performance. We hypothesized that the accumulation of MQ at the glucose sensor-tissue interface will act as "Cell Based Metabolic Barriers" (CBMB) to glucose diffusing from the interstitial tissue compartment to the implanted glucose sensor and as such creating an artificially low sensor output, thereby compromising sensor function and CGM. Our studies demonstrated that 1) direct injections of MQ at in vivo sensor implantation sites dramatically decreased sensor output (measured in nA), 2) addition of MQ to glucose sensors in vitro resulted in a rapid and dramatic fall in sensor output and 3) lymphocytes did not affect sensor function in vitro or in vivo. These data support our hypothesis that MQ can act as metabolic barriers to glucose and O2 diffusion in vivo and in vitro.

Indexed as

AnimalsBiosensing TechniquesDiffusionGlucoseMacrophagesMiceMice, Inbred C57BLGlucoseContinuous glucose monitoringDiabetesGlucose metabolismImplantable glucose sensorMacrophages

Identifiers

PMID24461328
PMCPMC3938107
OpenAlexW1981164033

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.