Evidence map›Paper›PMID 24461293›Full record

ArticleBioorganic & medicinal chemistry letters2014

Dual inhibition of HCV and HIV by ring-expanded nucleosides containing the 5:7-fused imidazo[4,5-e][1,3]diazepine ring system. In vitro results and implications.

Ning Zhang, Peng Zhang, Andrea Baier, Lucyna Cova, Ramachandra S Hosmane

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Ning ZhangLaboratory for Drug Design and Synthesis, Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA.
Peng ZhangLaboratory for Drug Design and Synthesis, Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA.
Andrea BaierDepartment of Molecular Biology, John Paul II Catholic University of Lublin, Lublin, Poland.
Lucyna CovaINSERM U871, Molecular Physiopathology & New Treatments of Viral Hepatitis, 151 Cours A. Thomas, 69003 Lyon Cedex 03, France.
Ramachandra S HosmaneLaboratory for Drug Design and Synthesis, Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA. Electronic address: hosmane@umbc.edu.
University of Maryland, Baltimore County · USInserm · FRJohn Paul II Catholic University of Lublin · PL

Funding

Inhibition of HCV as an Opportunistic HIV Co-infectionR01GM087738 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI FISHBEIN, JAMES C · 2008 to 2011
$1.3M
Mechanistic Studies of Anti-HIV Activity of a Novel Ring-Expanded NucleosideR21AI071802 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI HOSMANE, RAMACHANDRA S · 2006 to 2007
$512k
NIAID NIH HHS 1 R21 AI071802NIAID NIH HHS R21 AI071802NIGMS NIH HHS 1R01 GM087738-01A1NIGMS NIH HHS R01 GM087738
6 · The paper itself

Abstract

Examples of ring-expanded nucleosides (RENs), represented by general structures 1 and 2, exhibited dual anti-HCV and anti-HIV activities in both cell culture systems and the respective target enzyme assays, including HCV NTPase/helicase and human RNA helicase DDX3. Since HCV is a leading co-infection in late stage HIV AIDS patients, often leading to liver cirrhosis and death, the observed dual inhibition of HCV and HIV by the target nucleoside analogues has potentially beneficial implications in treating HIV patients infected with HCV.

Indexed as

Antiviral AgentsAzepinesDEAD-box RNA HelicasesDose-Response Relationship, DrugHepacivirusHIVHumansImidazolesMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAntiviral AgentsAzepinesDDX3X protein, humanDEAD-box RNA Helicasesimidazo(4,5-e)(1,3)diazepineImidazolesAntiviral compoundsDual inhibitors of HCV and HIVHepatitis C virus (HCV)Human immunodeficiency virus (HIV)Imidazo[4,5-e][1,3]diazepinesInhibition of HCV NTPase/helicaseInhibition of RNA helicase DDX3In vitro screeningOrganic synthesisRing-expanded nucleosides

Identifiers

PMID24461293
PMCPMC3979313
OpenAlexW2080446630

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.