ArticleAlcoholism, clinical and experimental research2014
Gamma-aminobutyric acid system genes--no evidence for a role in alcohol use and abuse in a community-based sample.
Article in Alcoholism, clinical and experimental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Prospective DNA Methylation Analysis of the CpG GABRA2 Receptor Subunit in Alcohol Dependence during Detoxification.Medicina (Kaunas, Lithuania) · 2022Article
- Alcohol in Psoriasis-From Bench to Bedside.International journal of molecular sciences · 2021Review
- Recent advances in genetic studies of alcohol use disorders.Current genetic medicine reports · 2020Article
- Effects of Common and Rare Chromosome 4 GABAergic Gene Variation on Alcohol Use and Antisocial Behavior.Journal of studies on alcohol and drugs · 2019Article
- GABAPsychopharmacology · 2018Review
- Intergenerational continuity in parents' and adolescents' externalizing problems: The role of life events and their interaction with GABRA2.Journal of abnormal psychology · 2015Article
- Genome-wide association data suggest ABCB1 and immune-related gene sets may be involved in adult antisocial behavior.Translational psychiatry · 2015Article
- Endophenotypes for Alcohol Use Disorder: An Update on the Field.Current addiction reports · 2015Article
- Heritability and molecular-genetic basis of resting EEG activity: a genome-wide association study.Psychophysiology · 2014Article
- Knowns and unknowns for psychophysiological endophenotypes: integration and response to commentaries.Psychophysiology · 2014Review
- Risky Business: Pathways to Progress in Biologically Informed Studies of Psychopathology.Psychological inquiryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWhile twin and adoption studies point to substantial genetic influence upon alcohol use, dependence, and other alcohol-related phenotypes, few of the genes underlying variation in these phenotypes have been identified. Markers in genes related to GABAergic activity-a system integral to many of alcohol's biological effects-have been implicated in alcohol use and alcohol-related psychopathology in linkage and association studies.
methodsUsing multiple methods, we conducted a comprehensive examination of the effects of markers in γ-aminobutyric acid (GABA) system genes in a community-based sample of 7,224 individuals assessed in early and middle adulthood. In addition to testing the effect of individual single nucleotide polymorphism (SNP) markers on alcohol-related phenotypes, we computed a polygenic score reflecting the aggregated effects of multiple GABA system SNPs. We also estimated the variance in alcohol-related phenotypes attributable to all GABA system markers considered simultaneously and conducted gene-based association tests.
resultsNo method produced results indicative of an effect of GABA system variants on measures of alcohol use or misuse.
conclusionsThese results reflect alcohol-related behaviors in a population-representative sample, many of whom are still in adolescence, and in which the incidence of heavy drinking and alcohol-related symptomatology are relatively low. Contrasted with existing studies of the association between alcohol use and GABA system genes, our results suggest that the relationship may be limited to particular contexts, such as when accompanied by polysubstance abuse or a familial history of alcoholism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.