ArticleBMC cancer2014
Influence of pain severity on the quality of life in patients with head and neck cancer before antineoplastic therapy.
Article in BMC cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05427058 (Hypogastric Plexus Block and Ganglion Impar Block for Cervical and Endometrial Cancer Pain Management), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hypogastric Plexus Block and Ganglion Impar Block for Cervical and Endometrial Cancer Pain Management: A Randomized Controlled Trial of Efficacy and Safety
Who cites it
22 citing papers in PubMed.
- Painful Realities: Navigating the Complexities of Head and Neck Cancer Pain.Oral diseases · 2025Review
- ''Mitigating cancer pain: What else matters?"-A qualitative study into the needs and concerns of cancer patients in Sri Lanka.PloS one · 2025Article
- Pain Management Adequacy in Patients With Bone Metastases: A Secondary Analysis From the Palliative Radiotherapy and Inflammation Study Trial.Clinical Medicine Insights. Oncology · 2025Article
- Patients' satisfaction with cancer pain treatment at adult oncologic centers in Northern Ethiopia; a multi-center cross-sectional study.BMC cancer · 2024Article
- Impact of COVID-19 pandemic among patients with lung and head and neck cancer assisted in a public cancer center in Brazil.BMC cancer · 2024Article
- Measurement of the Association of Pain with Clinical Characteristics in Oral Cancer Patients at Diagnosis and Prior to Cancer Treatment.Journal of pain research · 2024Article
- Impact of Salvage Surgery on Health-Related Quality of Life in Oral Squamous Cell Carcinoma: A Prospective Multi-Center Study.Journal of clinical medicine · 2023Article
- Temporal characterization of acute pain and toxicity kinetics during radiation therapy for head and neck cancer. A retrospective study.Oral oncology reports · 2023Article
- Pretreatment pain predicts perineural invasion in patients with head and neck squamous cell carcinoma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Adequacy of Pain Treatment in Radiotherapy Departments: Results of a Multicenter Study on 2104 Patients (Arise).Cancers · 2022Article
- Quality of Life of Patients After Treatment for Cancer in the Head and Neck Region: A Case-Control Study.Cureus · 2022Article
- Depiction of Oral Tumor-Induced Trigeminal Afferent Responses Using Single-Fiber Electrophysiology.Scientific reports · 2019Article
- Dental approach of orofacial pain in head and neck cancer patients.Journal of clinical and experimental dentistry · 2018Article
- Determinants of quality of life among Malaysian cancer patients: a cross-sectional study.Health and quality of life outcomes · 2018Article
- Cost-Effectiveness of Nivolumab in Recurrent Metastatic Head and Neck Squamous Cell Carcinoma.The oncologist · 2018Article
- Burden of cancer pain in developing countries: a narrative literature review.ClinicoEconomics and outcomes research : CEOR · 2018Review
- Investigation of Racial Disparities in Early Supportive Medication Use and End-of-Life Care Among Medicare Beneficiaries With Stage IV Breast Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016Article
- EXPRESS: BDNF Signaling Contributes to Oral Cancer Pain in a Preclinical Orthotopic Rodent Model.Molecular pain · 2016Article
- Mas-related G-protein-coupled receptor c agonist bovine adrenal medulla 8-22 attenuates bone cancer pain in mice.International journal of clinical and experimental medicine · 2015Article
- Is quality of life "the heart of the issue" in head and neck cancers?Indian journal of palliative care · 2014Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to assess the severity of pain and its impact on the quality of life (QoL) in untreated patients with head and neck squamous cell carcinoma (HNSCC).
methodsA study group of 127 patients with HNSCC were interviewed before antineoplastic treatment. The severity of pain was measured using the Brief Pain Inventory (BPI) questionnaire, and the QoL was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30) and the head and neck module (QLQ-H&N35).
resultsThe mean age of the patients was 57.9 years, and there was a predominance of men (87.4%). The most frequent site of the primary tumor was the oral cavity (70.6%), and the majority of the patients had advanced cancers (stages III and IV). QoL in early stage of cancer obtained better scores. Conversely, the patients with advanced stage cancer scored significantly higher on the symptom scales regarding fatigue, pain, appetite loss and financial difficulties, indicating greater difficulties. Regard to the severity of pain, patients with moderate-severe pain revealed a significantly worse score than patients without pain.
conclusionsThe severity of pain is statistically related to the advanced stages of cancer and directly affects the QoL. An assessment of the quality of life and symptoms before therapy can direct attention to the most important symptoms, and appropriate interventions can then be directed toward improving QoL outcomes and the response to treatment.
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