Evidence map›Paper›PMID 24460201›Full record

ReviewCell communication & adhesion2014

Integrating animal models and in vitro tissue models to elucidate the role of desmosomal proteins in diseases.

Maranke I Koster, Jason Dinella, Jiangli Chen, Charlene O'Shea, Peter J Koch

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell communication & adhesion, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Use of induced pluripotent stem cells in dermatological research.The Journal of investigative dermatology · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Maranke I KosterDepartment of Dermatology, University of Colorado School of Medicine and Charles C Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado School of Medicine , Aurora, CO , USA.
Jason Dinella
Jiangli Chen
Charlene O'Shea
Peter J Koch
Gates (United States) · USUniversity of Colorado Denver · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Cross-talk Between Desmosomal Proteins and Signaling Pathways in the SkinR01AR053892 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI KOCH, PETER J. · 2008 to 2012
$1.9M
The role of p63 in hair follicle stem cells and cancerR01AR061506 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI KOSTER, MARANKE I. · 2011 to 2015
$1.7M
Colorado Clinical and Translational Sciences InstituteTL1TR001081 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$1.3M
Elucidating the molecular pathology of ectodermal dysplasias caused by TP63 mutatR56AR066713 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI KOCH, PETER J., KOSTER, MARANKE I. · 2014 to 2015
$918k
The role of p63 in normal epidermal differentiation and ectodermal dysplasiasR00AR054696 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI KOSTER, MARANKE I. · 2009 to 2011
$747k
The role of p63 in normal epidermal differentiation and ectodermal dysplasiasK99AR054696 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI KOSTER, MARANKE I. · 2007 to 2008
$180k
NCATS NIH HHS TL1 TR001081NCATS NIH HHS TR001081NCATS NIH HHS UL1 TR001082NIAMS NIH HHS K99 AR054696NIAMS NIH HHS R00 AR054696NIAMS NIH HHS R01 AR053892NIAMS NIH HHS R01 AR061506NIAMS NIH HHS R56 AR066713
6 · The paper itself

Abstract

Desmosomes are intercellular junctions that provide tissues with structural stability. These junctions might also act as signaling centers that transmit environmental clues to the cell, thereby affecting cell differentiation, migration, and proliferation. The importance of desmosomes is underscored by devastating skin and heart diseases caused by mutations in desmosomal genes. Recent observations suggest that abnormal desmosomal protein expression might indirectly contribute to skin disorders previously not linked to these proteins. For example, it has been postulated that reduced desmosomal protein expression occurs in patients affected by Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (AEC), a skin fragility disorder caused by mutations in the transcription factor TP63. Currently, it is not clear how these changes in desmosomal gene expression contribute to AEC. We will discuss new approaches that combine in vitro and in vivo models to elucidate the role of desmosomal gene deregulation in human skin diseases such as AEC.

Indexed as

Models, BiologicalAnimalsCleft LipCleft PalateDesmocollinsDesmoplakinsDesmosomesEctodermal DysplasiaEye AbnormalitiesEyelidsHumansTranscription FactorsTumor Suppressor ProteinsDesmocollinsDesmoplakinsTP63 protein, humanTranscription FactorsTumor Suppressor Proteins

Identifiers

PMID24460201
PMCPMC4117210
OpenAlexW1997690612

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.