ArticleThe world journal of men's health2013
Preliminary report on the safety of a new herbal formula and its effect on sperm quality.
Article in The world journal of men's health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- The most important medicinal plants affecting sperm and testosterone production: a systematic review.JBRA assisted reproduction · 2022Pooled it
- A Review of Traditional Chinese Medicine Formulations and Natural Active Ingredients with Therapeutic Potential for Male Infertility Targeting Oxidative Stress.Pharmaceuticals (Basel, Switzerland) · 2025Review
- The impact of infertility-related stress, physiological stress and some fertility indices on clinical pregnancy in women undergoing in vitro fertilization.BMC pregnancy and childbirth · 2025Article
- Combined treatment with extracorporeal shockwaves therapy and an herbal formulation for activation of penile progenitor cells and antioxidant activity in diabetic erectile dysfunction.Translational andrology and urology · 2020Article
- Characterization of theEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Antagonistic Effect of Cuscuta chinensis on a Rat Model with Unilateral Cryptorchidism.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Effects of a combination of herbal extracts (modified Ojayeonjonghwan (Wuzi Yanzong wan)) on partial urethral obstruction-induced detrusor overactivity in rats: impact on the nitric oxide pathway and oxidative stress.BMC complementary and alternative medicine · 2019Article
- Effect of Korean Herbal Formula (Modified Ojayeonjonghwan) on Androgen Receptor Expression in an Aging Rat Model of Late Onset Hypogonadism.The world journal of men's health · 2019Article
- The Therapeutic Effects of Traditional Chinese Medicine for Poor Semen Quality in Infertile Males.Journal of clinical medicine · 2018Article
- Observational
- Antioxidant and Antifibrotic Effect of a Herbal FormulationOxidative medicine and cellular longevity · 2017Article
- Effects of KH-204 on the expression of heat shock protein 70 and germ cell apoptosis in infertility rat models.BMC complementary and alternative medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMale infertility is a serious problem, and its prevalence has been increasing. Therefore, we investigated the safety of a new herbal formula and its effects on sperm quality. MATERIALS AND
methodsAn in vitro cytotoxicity test in TM3 Leydig cells was performed to evaluate cell viability after administration of five types of herbs separately and of a new herbal formula containing these five. An in vivo test in male mice was performed to evaluate the influence of the new herbal formula on the reproductive organs and sperm quality. After the 8- and 28-day oral administration of the new herbal formula, the weights of the reproductive organs were measured and the sperm count and motility were evaluated.
resultsIn the in vitro cytotoxicity test, less than 80% cell viability at concentrations of 500 mg/L and 1,000 mg/L of Rubus coreanus Miquel and Cuscuta chinensis Lam was observed. However, more than 80% cell viability was observed at all the tested concentrations of the new herbal formula. After the 8- and 28-day oral administration, there were no considerable changes in body weight. The weights of the testes, epididymis, and seminal vesicles after the 8- and 28-day oral administration were similar to those of the control. The sperm count and activity were significantly improved compared with those of the control group at 8 and 28 days after 100, 200, and 400 mg of oral administration.
conclusionsThe safety of the new formula and its positive effect on the sperm quality were observed after the oral administration of the formula.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.