Evidence map›Paper›PMID 24459653›Full record

ReviewThe world journal of men's health2013

Low-intensity shock wave therapy and its application to erectile dysfunction.

Hongen Lei, Jing Liu, Huixi Li, Lin Wang, Yongde Xu, Wenjie Tian, Guiting Lin, Zhongcheng Xin

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The world journal of men's health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02683044 (Randomized Clinical Trial To Evaluate The Comparative Effectiveness And Safety Of Two Protocols For The Treatment Of Erectile Dysfunction With Low-Density Shock Waves), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02683044 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Randomized Clinical Trial To Evaluate The Comparative Effectiveness And Safety Of Two Protocols For The Treatment Of Erectile Dysfunction With Low-Density Shock Waves

TypeinterventionalSponsorInstituto para la Evaluación de la Calidad y Atención en SaludRan2016 to 2017Enrolled206ConditionsErectile DysfunctionArmsLow-Intensity Extracorporeal Shock Wave Therapy (Li-ESWT)
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Hongen LeiAndrology Center, Department of Urology, Peking University First Hospital, Peking University, Beijing, China.
Jing LiuAndrology Center, Department of Urology, Peking University First Hospital, Peking University, Beijing, China.
Huixi LiAndrology Center, Department of Urology, Peking University First Hospital, Peking University, Beijing, China.
Lin WangAndrology Center, Department of Urology, Peking University First Hospital, Peking University, Beijing, China.
Yongde XuAndrology Center, Department of Urology, Peking University First Hospital, Peking University, Beijing, China.
Wenjie TianDepartment of Urology, China-Japan Union Hospital of Jilin University, Jilin, China.
Guiting LinKnuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA.
Zhongcheng XinAndrology Center, Department of Urology, Peking University First Hospital, Peking University, Beijing, China.
Peking University · CNPeking University First Hospital · CNJilin University · CNUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although phosphodiesterase type 5 inhibitors (PDE5Is) are a revolution in the treatment of erectile dysfunction (ED) and have been marketed since 1998, they cannot restore pathological changes in the penis. Low-energy shock wave therapy (LESWT) has been developed for treating ED, and clinical studies have shown that LESWT has the potential to affect PDE5I non-responders with ED with few adverse effects. Animal studies have shown that LESWT significantly improves penile hemodynamics and restores pathological changes in the penis of diabetic ED animal models. Although the mechanisms remain to be investigated, recent studies have reported that LESWT could partially restore corpus cavernosum fibromuscular pathological changes, endothelial dysfunction, and peripheral neuropathy. LESWT could be a novel modality for treating ED, and particularly PDE5I non-responders with organic ED, in the near future. However, further extensive evidence-based basic and clinical studies are needed. This review intends to summarize the scientific background underlying the effect of LESWT on ED.

Indexed as

Erectile dysfunctionESWLExtracorporeal shockwave lithotripsyPhosphodiesterase 5 inhibitors

Identifiers

PMID24459653
PMCPMC3888889
OpenAlexW2082786897

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.