Evidence map›Paper›PMID 24459527›Full record

ReviewElectrolyte & blood pressure : E & BP2008

Magnesium metabolism.

Jang Won Seo, Tae Jin Park

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Electrolyte & blood pressure : E & BP, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04166877 (Magnesium Infusion for Pain Management in Critically Ill Trauma Patients), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04166877 phase4recruitingnot on this mapstarted 2019, after this paper: background citation

Magnesium Infusion for Pain Management in Critically Ill Trauma Patients

TypeinterventionalSponsorUniversity of California, DavisRan2019 to 2026Enrolled156ConditionsTrauma, Acute PainArmsMagnesium Sulfate in Parenteral Dosage Form, Normal saline placebo
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Aquaporin Modulation by Cations, a Review.Current issues in molecular biology · 2024
    Review
  11. Review
  12. Article
  13. Hypermagnesemia in Clinical Practice.Medicina (Kaunas, Lithuania) · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. 'Magnesium'-the master cation-as a drug-possibilities and evidences.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jang Won SeoDepartment of Internal Medicine, College of Medicine and Kidney Research Institute, Hallym University, Seoul, Korea.
Tae Jin ParkDepartment of Internal Medicine, College of Medicine and Kidney Research Institute, Hallym University, Seoul, Korea.
Hallym University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnesium is the second most common intracellular divalent cation. Magnesium balance in the body is controlled by a dynamic interplay among intestinal absorption, exchange with bone, and renal excretion. Intestinal magnesium absorption proceeds in both a passive paracellular and an active transcellular manner. Regulation of serum magnesium concentrations is achieved mainly by control of renal magnesium reabsorption. Only 20% of filtered magnesium is reabsorbed in the proximal tubule, whereas 60% is reclaimed in the cortical thick ascending limb (TAL) and another 5-10% in the distal convoluted tubule (DCT). The passive paracellular transport of magnesium in the TAL is closely related with the mutations in claudin-16/paracellin-1 and is responsible for familial hypomagnesemia with hypercalciuria and nephrocalcinosis. The active transcellular transport of magnesium in the DCT was similarly enhanced by the realization that defects in transient receptor potential melastatin 6 (TRPM6) cause hypomagnesemia with secondary hypocalcemia. This channel regulates the apical entry of magnesium into epithelia and alters whole-body magnesium homeostasis by controlling urinary excretion. TRPM6 is regulated at the transcriptional level by acid-base status, 17β-estradiol, and both FK506 and cyclosporine. The molecular identity of the protein responsible for the basolateral exit of magnesium from the epithelial cell remains unidentified.

Indexed as

homeostasismagnesiumparacellular transporttranscellular transporttransient receptor potential channels

Identifiers

PMID24459527
PMCPMC3894481
OpenAlexW4231910557

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.