ArticleResearch in pharmaceutical sciences2013
Preparation and assessment of chitosan-coated superparamagnetic Fe3O4 nanoparticles for controlled delivery of methotrexate.
Article in Research in pharmaceutical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Sub-15 nm Nanoparticles for Drug Delivery: Emerging Frontiers and Therapeutic Potential.International journal of molecular sciences · 2025Review
- A magnetic-guided nano-antibacterial platform for alternating magnetic field controlled vancomycin release in staphylococcus aureus biofilm eradication.Drug delivery and translational research · 2025Article
- Article
- Magnetic nanoparticles and possible synergies with cold atmospheric plasma for cancer treatment.RSC advances · 2024Review
- Functionalized Magnetic FeInternational journal of molecular sciences · 2024Article
- Magnetic Composites of Dextrin-Based Carbonate Nanosponges and Iron Oxide Nanoparticles with Potential Application in Targeted Drug Delivery.Nanomaterials (Basel, Switzerland) · 2022Article
- Fertility and Iron Bioaccumulation inMolecules (Basel, Switzerland) · 2021Article
- Synthesis and characterization of magnetic nanocomposite for in vitro evaluation of irinotecan using human cell lines.Turkish journal of chemistry · 2021Article
- Polyethylene Glycol-Chitosan Oligosaccharide-Coated Superparamagnetic Iron Oxide Nanoparticles: A Novel Drug Delivery System for Curcumin Diglutaric Acid.Biomolecules · 2020Article
- Development, evaluation and optimization of superparamagnetite nanoparticles prepared by co-precipitation method.Research in pharmaceutical sciences · 2017Article
- Thin chitosan films containing super-paramagnetic nanoparticles with contrasting capability in magnetic resonance imaging.Journal of materials science. Materials in medicine · 2017Article
- Single step synthesis, characterization and applications of curcumin functionalized iron oxide magnetic nanoparticles.Materials science & engineering. C, Materials for biological applications · 2016Article
- Antimicrobial activity of iron oxide nanoparticle upon modulation of nanoparticle-bacteria interface.Scientific reports · 2015Article
- The impact of polymer coatings on magnetite nanoparticles performance as MRI contrast agents: a comparative study.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2015Article
- Effects of magnetic nanoparticles of Fe3O4 combinated with gambogic acid on apoptosis of SMMC-7721 cells.OncoTargets and therapy · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, Fe3O4 superparamagnetic nanoparticles were synthesized and stabilized by chitosan. Then the nanoparticles were characterized by Fourier transform infrared spectroscopy and transmission electron microscopy (TEM). Particle size distribution and Zeta potential of the particles also was assessed using Malvern Zetasizer. The paramagnetic behaviors of the uncoated and chitosan coated nanoparticles were measured using vibrating scanning magnetometry Particles morphology and size ranges of uncoated iron oxide nanoparticles were evaluated by TEM, showing uniform and narrow size distribution about 10 nm. After coating nanoparticles with chitosan and loading of methotrexate (MTX), the change in size was assessed using Zetasizer. Considerable increase in size was observed following the coating of the particles with chitosan and loading with MTX (the average size was 152 nm). Paramagnetic properties of the uncoated and chitosan-coated particles were assessed showing significant decrease in paramagnetic behavior after coating with chitosan, but it was enough to respond to the magnetic field. Finally loading efficiency, release rate and cytotoxicity of MTX were assessed indicating slow release behavior with the same levels of cell toxicity in SK-BR-3 cell lines, suggesting this formulation as a good candidate for the controlled delivery of MTX.
Indexed as
Identifiers
24459473PMC3895297What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.