ArticleResearch in pharmaceutical sciences2013
Inhibitory effect of Rosa damascena Mill flower essential oil, geraniol and citronellol on rat ileum contraction.
Article in Research in pharmaceutical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- Effects of Rosa damascena and its compounds on smooth muscle contractility.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2026Review
- Unveiling the genetic basis of floral scent formation in roses using weighted gene co-expression and protein-protein interaction network analyses.Scientific reports · 2025Article
- The effects of rose oil on liver damage in an experimental model of obstructive jaundice.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2025Article
- Investigation of genes involved in scent and color production in Rosa damascena Mill.Scientific reports · 2024Article
- A study on the effect of natural products against the transmission of B.1.1.529 Omicron.Virology journal · 2023Review
- Rose Flowers-A Delicate Perfume or a Natural Healer?Biomolecules · 2021Review
- Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources.Frontiers in pharmacology · 2021Review
- Article
- A Systematic Review on the Anxiolytic Effect of Aromatherapy during the First Stage of Labor.Journal of caring sciences · 2019Review
- Geraniol Protects Against the Protein and Oxidative Stress Induced by Rotenone in an In Vitro Model of Parkinson's Disease.Neurochemical research · 2018Article
- Antilisterial Effect ofBioMed research international · 2018Article
- Natural Antispasmodics: Source, Stereochemical Configuration, and Biological Activity.BioMed research international · 2018Review
- Traditional Persian topical medications for gastrointestinal diseases.Iranian journal of basic medical sciences · 2017Review
- Rosa damascena as holy ancient herb with novel applications.Journal of traditional and complementary medicine · 2016Review
- Chemical Composition and Vasorelaxant and Antispasmodic Effects of Essential Oil from Rosa indica L. Petals.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Antispasmodic and antidiarrhoeal activity of the fruit of Rosa moschata (J).BMC complementary and alternative medicine · 2014Article
- In Vitro Impact of Hydro-alcoholic Extract of Rosa damascena Mill. on Rat Ileum Contractions and the Mechanisms Involved.International journal of preventive medicine · 2014Article
- Effect of Rosa damascena Mill. flower extract on rat ileum.Research in pharmaceutical sciences · 2013Article
- Effect of aqueous fraction of Rosa damascena on ileum contractile response of guinea pigs.Avicenna journal of phytomedicine · 2013Article
- Assessment of hydroalcoholic and hexane extracts of Rosa persica Mich. flower on rat ileum spasm.Research in pharmaceutical sciencesArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flower of Rosa damascena Mill is widely used in Iran for gastrointestinal (GI) disorders. However, its pharmacological action on ileum contraction has not been studied. In this research we have investigated ileum motility effect of essential oil of flower petals of R. damascena growing in Kashan, Iran, and two of its constituents. The essential oils obtained by hydrodistillation were investigated by a combination of GC and GC/MS. More than 34 compounds have been identified. The main constituents of the essential oil were β-citronellol (23%), nonadecane (16%), geraniol (16%) and heneicosane (5%). A portion of rat isolated ileum was suspended under 1g tension in Tyrode's solution at 37°C and gassed with O2. Effect of the R. damascena essential oil (2.5-160 μg/ml), geraniol (0.2-3.2 μg/ml) and citronellol (0.8-6.4 μg/ml) were studied on ileum contractions induced by KCl, acetylcholine (ACh) and electrical field stimulation (EFS) and compared with standard drugs atropine and loperamide. The contractile response of EFS was mediated mainly through the intramural nerve plexuses, because its response was inhibited by loperamide and partially reduced by atropine. The essential oil concentration dependently inhibited the response to KCl (IC50=67 ± 8.4μg/ml) and EFS (IC50=47 ± 10.6 μg/ml). Geraniol (IC50=1.7 ± 0.15 μg/ml for KCl) and citronellol (IC50=2.9 ± 0.3 μg/ml for KCl) also had inhibitory effect of ileum contraction and both were more potent than the essential oil. It was concluded that R. damascena essential oil mainly had an inhibitory effect on ileum contractions and geraniol and citronellol had a major role in inhibitory effect of the essential.
Indexed as
Identifiers
24459472PMC3895296W2110397379What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.