Evidence map›Paper›PMID 24459330›Full record

ArticleMediators of inflammation2013

Proteinase-activated receptor-1 and immunomodulatory effects of a PAR1-activating peptide in a mouse model of prostatitis.

M Mark Stanton, Lisa K Nelson, Hallgrimur Benediktsson, Morley D Hollenberg, Andre G Buret, Howard Ceri

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

M Mark StantonDepartment of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4 ; Inflammation Research Network, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4 ; Biofilm Research Group, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4.
Lisa K NelsonDepartment of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4 ; Inflammation Research Network, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4 ; Biofilm Research Group, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4.
Hallgrimur BenediktssonDepartment of Pathology and Laboratory Medicine, Calgary Laboratory Services, Foothills Medical Centre, 1403 29 Street NW, Calgary, AB, Canada T2N 2T9.
Morley D HollenbergInflammation Research Network, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4 ; Department of Physiology and Pharmacology, University of Calgary Health Sciences Center, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1.
Andre G BuretDepartment of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4 ; Inflammation Research Network, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4 ; Biofilm Research Group, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4.
Howard CeriDepartment of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4 ; Inflammation Research Network, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4 ; Biofilm Research Group, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4.
University of Calgary · CAFoothills Medical Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNonbacterial prostatitis has no established etiology. We hypothesized that proteinase-activated receptor-1 (PAR1) can play a role in prostatitis. We therefore investigated the effects of PAR1 stimulation in the context of a new model of murine nonbacterial prostatitis.

methodsUsing a hapten (ethanol-dinitrobenzene sulfonic acid- (DNBS-)) induced prostatitis model with both wild-type and PAR1-null mice, we examined (1) the location of PAR1 in the mouse prostate and (2) the impact of a PAR1-activating peptide (TFLLR-NH2: PAR1-TF) on ethanol-DNBS-induced inflammation.

resultsEthanol-DNBS-induced inflammation was maximal at 2 days. In the tissue, PAR1 was expressed predominantly along the apical acini of prostatic epithelium. Although PAR1-TF on its own did not cause inflammation, its coadministration with ethanol-DNBS reduced all indices of acute prostatitis. Further, PAR1-TF administration doubled the prostatic production of interleukin-10 (IL-10) compared with ethanol-DNBS treatment alone. This enhanced IL-10 was not observed in PAR1-null mice and was not caused by the reverse-sequence receptor-inactive peptide, RLLFT-NH2. Surprisingly, PAR1-TF, also diminished ethanol-DNBS-induced inflammation in PAR1-null mice.

conclusionsPAR1 is expressed in the mouse prostate and its activation by PAR1-TF elicits immunomodulatory effects during ethanol-DNBS-induced prostatitis. However, PAR1-TF also diminishes ethanol-DNBS-induced inflammation via a non-PAR1 mechanism by activating an as-yet unknown receptor.

Indexed as

AnimalsAnti-Inflammatory AgentsDinitrofluorobenzeneDisease Models, AnimalEthanolImmunologic FactorsInterleukin-10MaleMiceMice, Inbred C57BLOligopeptidesProstatitisReceptor, PAR-12,4-dinitrofluorobenzene sulfonic acidAnti-Inflammatory AgentsDinitrofluorobenzeneEthanolImmunologic FactorsInterleukin-10OligopeptidesPAR-1-activating peptideReceptor, PAR-1

Identifiers

PMID24459330
PMCPMC3891427
OpenAlexW2048520960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.