Evidence map›Paper›PMID 24459154›Full record

SynthesisDiabetes care2014

Caffeinated and decaffeinated coffee consumption and risk of type 2 diabetes: a systematic review and a dose-response meta-analysis.

Ming Ding, Shilpa N Bhupathiraju, Mu Chen, Rob M van Dam, Frank B Hu

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetes care, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06330727 (Effects of Three-Month Coffee Consumption on Metabolic Biomarkers in Adults With Prediabetes and Obesity), which is not on this map. Cited by 218 papers, 22 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
218citing papers in PubMed, 22 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06330727 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Effects of Three-Month Coffee Consumption on Metabolic Biomarkers in Adults With Prediabetes and Obesity: a Randomized, Double-blind, Placebo-controlled Clinical Trial

TypeinterventionalSponsorNanjing First Hospital, Nanjing Medical UniversityRan2024 to 2024Enrolled100ConditionsPrediabetesArmsCoffee capsule, Corn starch capsule
3 · Its place in the literature

Who cites it

218 citing papers in PubMed, 22 syntheses or guidelines pooled it.

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  3. The Effects of Caffeine on Anxiety Behavior in Healthy Individuals: A Systematic Review of the Literature.Stress and health : journal of the International Society for the Investigation of Stress · 2026
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158 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Ming DingCorresponding author: Frank B. Hu, nhbfh@channing.harvard.edu.
Shilpa N Bhupathiraju
Mu Chen
Rob M van Dam
Frank B Hu

Funding

BIOCHEMICAL AND GENETIC MARKERS OF TYPE 2 DIABETES RISKR01DK058845 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, FRANK B · 2001 to 2013
$7.8M
NIDDK NIH HHS DK-58845NIDDK NIH HHS R01 DK058845
6 · The paper itself

Abstract

objectivePrevious meta-analyses identified an inverse association of coffee consumption with the risk of type 2 diabetes. However, an updated meta-analysis is needed because new studies comparing the trends of association for caffeinated and decaffeinated coffee have since been published. RESEARCH DESIGN AND

methodsPubMed and Embase were searched for cohort or nested case-control studies that assessed the relationship of coffee consumption and risk of type 2 diabetes from 1966 to February 2013. A restricted cubic spline random-effects model was used.

resultsTwenty-eight prospective studies were included in the analysis, with 1,109,272 study participants and 45,335 cases of type 2 diabetes. The follow-up duration ranged from 10 months to 20 years. Compared with no or rare coffee consumption, the relative risk (RR; 95% CI) for diabetes was 0.92 (0.90-0.94), 0.85 (0.82-0.88), 0.79 (0.75-0.83), 0.75 (0.71-0.80), 0.71 (0.65-0.76), and 0.67 (0.61-0.74) for 1-6 cups/day, respectively. The RR of diabetes for a 1 cup/day increase was 0.91 (0.89-0.94) for caffeinated coffee consumption and 0.94 (0.91-0.98) for decaffeinated coffee consumption (P for difference = 0.17).

conclusionsCoffee consumption was inversely associated with the risk of type 2 diabetes in a dose-response manner. Both caffeinated and decaffeinated coffee was associated with reduced diabetes risk.

Indexed as

CoffeeCaffeineDiabetes Mellitus, Type 2Dose-Response Relationship, DrugFemaleHumansMaleMiddle AgedRisk FactorsSurveys and QuestionnairesCaffeineCoffee

Identifiers

PMID24459154
PMCPMC3898757

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.