ArticleScience (New York, N.Y.)2014
A peptide hormone and its receptor protein kinase regulate plant cell expansion.
Article in Science (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 393 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
393 citing papers in PubMed, 1 synthesis or guideline pooled it, 824 citations in OpenAlex.
- Root hair growth from the pH point of view.Frontiers in plant science · 2022Pooled it
- Biosensors reveal distinct cytosolic pH and redox dynamics across seedlings in response to danger signals and pathogen infection.Journal of experimental botany · 2026Article
- The Plant Cell Wall: From Structural Diversity and Biosynthesis to Integrity Signaling and Physiological Functions.Plants (Basel, Switzerland) · 2026Review
- Peptide hormones in shaping root system architecture and environmental adaptation: Current advances and translational perspectives.Plant communications · 2026Review
- PlantCCC prioritizes context-specific candidate ligand-receptor communication patterns in plant spatial transcriptomics.Plant molecular biology · 2026Article
- Quantitative imaging of apoplastic pH in plant roots via confocal microscopy.Nature protocols · 2026Review
- Cotton Salt Stress Resilience: Integrating Physiological, Molecular, and Agronomic Strategies for Next-Generation Breeding.Plant, cell & environment · 2026Review
- Pectin Structural Dynamics: Developmental and Evolutionary Perspectives.Plants (Basel, Switzerland) · 2026Review
- Endogenous RALF peptide function is required for powdery mildew host colonization.The New phytologist · 2026Article
- Structural Features of Root Cells ofInternational journal of molecular sciences · 2026Article
- Dual role of the receptor kinase FERONIA in regulating tissue mechanics and growth.Science advances · 2026Article
- Evolution trajectory of auxin response factor across Triticeae species underpin candidate genes for the regulation of salt/alkali stress responsive networks.Plant cell reports · 2026Article
- Ubiquitination of the ribosomal-like domain of UBIQUITIN6 contributes to cell wall stress responses in Arabidopsis.The Plant cell · 2026Article
- Ancient peptide-redox signalling underlies sperm motility in Marchantia.Nature plants · 2026Article
- Multiomics analyses of mutants for Marchantia polymorpha FERONIA and MARIS reveal a link between cell wall integrity and abscisic acid responses.Plant & cell physiology · 2026Article
- Subfamily-level comparative transcriptomics of key immune regulators in plants and suspension cells reveals novel rice blast resistance genes.Plant & cell physiology · 2026Article
- Phosphatidic acid-driven plasma membrane localization and activation of FER confer salt tolerance inScience advances · 2026Article
- Advances in the roles of SCOOP peptides and the receptor-like kinase MIK2 in plant stress responses.Plant cell reports · 2026Review
- OsRALF26 Serves as an Endogenous Signal Recognised by XA21 to Promote Robust and Distal Resistance in Rice.Plant biotechnology journal · 2026Article
- A RALF22-like Peptide Coordinates Salt Tolerance and Disease Susceptibility in Poplar (Plants (Basel, Switzerland) · 2026Article
333 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Plant cells are immobile; thus, plant growth and development depend on cell expansion rather than cell migration. The molecular mechanism by which the plasma membrane initiates changes in the cell expansion rate remains elusive. We found that a secreted peptide, RALF (rapid alkalinization factor), suppresses cell elongation of the primary root by activating the cell surface receptor FERONIA in Arabidopsis thaliana. A direct peptide-receptor interaction is supported by specific binding of RALF to FERONIA and reduced binding and insensitivity to RALF-induced growth inhibition in feronia mutants. Phosphoproteome measurements demonstrate that the RALF-FERONIA interaction causes phosphorylation of plasma membrane H(+)-adenosine triphosphatase 2 at Ser(899), mediating the inhibition of proton transport. The results reveal a molecular mechanism for RALF-induced extracellular alkalinization and a signaling pathway that regulates cell expansion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.