ArticleJournal of assisted reproduction and genetics2014
Altered cleavage patterns in human tripronuclear embryos and their association to fertilization method: a time-lapse study.
Article in Journal of assisted reproduction and genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Scoping review on the embryonic developmental potential of tripronuclear zygotes and their use for clinical and research purposes.Journal of assisted reproduction and genetics · 2025Article
- Good practice recommendations for the use of time-lapse technologyHuman reproduction open · 2020Article
- Germline genome editing versus preimplantation genetic diagnosis: Is there a case in favour of germline interventions?Bioethics · 2020Article
- Human germline genome editing.Nature cell biology · 2019Review
- Functional Analysis of Human Pathological Semen Samples in an Oocyte Cytoplasmic Ex Vivo System.Scientific reports · 2018Article
- Live birth rate and number of blastomeres on day 2 transfer.Journal of assisted reproduction and genetics · 2016Article
- Morphokinetic Characteristics and Developmental Potential of In Vitro Cultured Embryos from Natural Cycles in Patients with Poor Ovarian Response.BioMed research international · 2016Article
- Morphokinetic parameters of early embryo development via time lapse monitoring and their effect on embryo selection and ICSI outcomes: a prospective cohort study.Journal of assisted reproduction and genetics · 2015Article
- The parental origin correlates with the karyotype of human embryos developing from tripronuclear zygotes.Clinical and experimental reproductive medicine · 2015Article
- Triploidy--Observations in 154 Diandric Cases.PloS one · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyze the cleavage patterns in dipronuclear (2PN) and tripronuclear (3PN) embryos in relation to fertilization method.
methodTime-lapse analysis.
resultsCompared to 2PN, more 3PN IVF embryos displayed early cleavage into 3 cells (p < 0.001), displayed longer duration of the 3-cell stage (p < 0.001), and arrested development from the compaction stage and onwards (p < 0.001). For the IVF embryos, the 2nd and 3rd cleavage cycles were completed within the expected time frame. However, timing of the cell divisions within the cleavage cycles differed between the two groups. In contrast, the completion of the 1st, 2nd, and 3rd cleavage cycle was delayed, but with a similar division pattern for 3PN ICSI compared with the 2PN ICSI embryos. 3PN, more often than 2PN ICSI embryos, displayed early cleavage into 3 cells (p = 0.03) and arrested development from the compaction stage and onwards (p = 0.001). More 3PN IVF than ICSI embryos displayed early cleavage into 3 cells (p < 0.001).
conclusionsThis study reports differences in cleavage patterns between 2PN and 3PN embryos and for the first time demonstrates differences in the cleavage pattern between 3PN IVF and ICSI embryos.
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