Evidence map›Paper›PMID 24458311›Full record

ArticleChest2014

A comparison of health-related quality of life in idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis.

Molly Lubin, Hubert Chen, Brett Elicker, Kirk D Jones, Harold R Collard, Joyce S Lee

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Health-related quality of life of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2020
    Pooled it
  3. Pooled it
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  19. Hypersensitivity pneumonitis.Nature reviews. Disease primers · 2020
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Molly LubinDepartment of Medicine, Department of Radiology, Department of Pathology, University of California, San Francisco, CA.
Hubert ChenGenentech, South San Francisco, CA.
Brett ElickerDepartment of Medicine, Department of Radiology, Department of Pathology, University of California, San Francisco, CA.
Kirk D JonesDepartment of Medicine, Department of Radiology, Department of Pathology, University of California, San Francisco, CA.
Harold R CollardDepartment of Medicine, Department of Radiology, Department of Pathology, University of California, San Francisco, CA.
Joyce S LeeDepartment of Medicine, Department of Radiology, Department of Pathology, University of California, San Francisco, CA. Electronic address: joyce.lee@ucsf.edu.

Funding

Clinical and Transtional Science InstituteKL2TR000143 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$11.9M
NCATS NIH HHS KL2 TR000143
6 · The paper itself

Abstract

backgroundPatients with interstitial lung disease (ILD) have poor health-related quality of life (HRQL). However, whether HRQL differs among different subtypes of ILD is unclear. The aim of this study was to determine whether HRQL was different among patients with idiopathic pulmonary fibrosis (IPF) and chronic hypersensitivity pneumonitis (CHP).

methodsWe identified patients from an ongoing longitudinal cohort of patients with ILD. HRQL was assessed using the Short Form (SF)-36 medical outcomes form (version 2.0). Regression analysis was used to determine the association between clinical covariates and HRQL, primarily the physical component summary (PCS) and mental component summary (MCS) score. A multivariate regression model was created to identify potential covariates that could help explain the association between the ILD subtype and HRQL.

resultsPatients with IPF (n = 102) were older, more likely to be men, and more likely to have smoked. Pulmonary function was similar between the groups. The patients with CHP (n = 69) had worse HRQL across all eight domains of the SF-36, as well as the PCS and MCS, compared with patients with IPF (P < .01-.09). This pattern remained after controlling for age and pulmonary function (P < .01-.02). Covariates explaining part of the relationship between disease subtype and PCS score included severity of dyspnea (P < .01) and fatigue (P < .01). Covariates explaining part of the relationship between disease subtype and MCS score included severity of dyspnea (P < .01), female sex (P = .02), and fatigue (P = .02).

conclusionsHRQL is worse in CHP compared with IPF. HRQL differences between ILD subtypes are explained in part by differences in sex, dyspnea, and fatigue.

Indexed as

Quality of LifeAgedAge FactorsAlveolitis, Extrinsic AllergicChronic DiseaseCohort StudiesComorbidityDyspneaFatigueFemaleHealth StatusHumansIdiopathic Pulmonary FibrosisLongitudinal StudiesMaleMiddle Aged

Identifiers

PMID24458311
PMCPMC4042514

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.