ArticleBlood2014
TPO signal for stem cell genomic integrity.
Article in Blood, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- The Involvement of Canonical NFκB Pathway in Megakaryocyte Differentiation Induction by Nanocurcumin.International journal of hematology-oncology and stem cell research · 2023Article
- Non-Hodgkin's lymphoma in an elderly patient with renal dysfunction: a case report.The Journal of international medical research · 2020Article
- The thrombopoietin mimetic romiplostim leads to the complete rescue of mice exposed to lethal ionizing radiation.Scientific reports · 2018Article
- Pathogenesis of Myeloproliferative Neoplasms: Role and Mechanisms of Chronic Inflammation.Mediators of inflammation · 2015Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this issue of Blood, de Laval et al report on a novel mechanism by which hematopoietic stem cells (HSCs) harboring DNA damage are rescued by thrombopoietin (TPO)-mediated DNA repair.1 It has been recently demonstrated that HSCs use the error-prone nonhomologous end-joining (NHEJ) pathway of DNA repair to fix DNA breaks. Maintenance of genomic integrity is crucial for HSC function. Finding the players involved in HSC DNA repair will provide a better understanding of hematopoietic homeostasis, HSC aging, and leukemogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.