ArticleScientific reports2014
Two modes of exocytosis in an artificial cell.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Research progress on the regulatory role of cell membrane surface tension in cell behavior.Heliyon · 2024Review
- Understanding the interplay of membrane trafficking, cell surface mechanics, and stem cell differentiation.Seminars in cell & developmental biology · 2023Review
- Reconstructing Soma-Soma Synapse-like Vesicular Exocytosis with DNA Origami.ACS central science · 2021Article
- Mechanics of Pollen Tube Elongation: A Perspective.Frontiers in plant science · 2020Review
- Electrochemistry at the Synapse.Annual review of analytical chemistry (Palo Alto, Calif.) · 2019Review
- Receptor-Ligand Rebinding Kinetics in Confinement.Biophysical journal · 2019Article
- Could vesicular transport of Na+ and Cl- be a feature of salt tolerance in halophytes?Annals of botany · 2019Article
- Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients.Journal of visualized experiments : JoVE · 2018Article
- Single Synaptic Observation of Cholinergic Neurotransmission on Living Neurons: Concentration and Dynamics.Journal of the American Chemical Society · 2018Article
- Amperometry methods for monitoring vesicular quantal size and regulation of exocytosis release.Pflugers Archiv : European journal of physiology · 2018Review
- Mitochondrial Nanotunnels.Trends in cell biology · 2017Review
- Article
- Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- 'Full fusion' is not ineluctable during vesicular exocytosis of neurotransmitters by endocrine cells.Proceedings. Mathematical, physical, and engineering sciences · 2017Article
- Cholesterol Alters the Dynamics of Release in Protein Independent Cell Models for Exocytosis.Scientific reports · 2016Article
- Variations in Fusion Pore Formation in Cholesterol-Treated Platelets.Biophysical journal · 2016Article
- All-carbon multi-electrode array for real-time in vitro measurements of oxidizable neurotransmitters.Scientific reports · 2016Article
- Mimicking subsecond neurotransmitter dynamics with femtosecond laser stimulated nanosystems.Scientific reports · 2014Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The details of exocytosis, the vital cell process of neuronal communication, are still under debate with two generally accepted scenarios. The first mode of release involves secretory vesicles distending into the cell membrane to release the complete vesicle contents. The second involves partial release of the vesicle content through an intermittent fusion pore, or an opened or partially distended fusion pore. Here we show that both full and partial release can be mimicked with a single large-scale cell model for exocytosis composed of material from blebbing cell plasma membrane. The apparent switching mechanism for determining the mode of release is demonstrated to be related to membrane tension that can be differentially induced during artificial exocytosis. These results suggest that the partial distension mode might correspond to an extended kiss-and-run mechanism of release from secretory cells, which has been proposed as a major pathway of exocytosis in neurons and neuroendocrine cells.
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