ReviewAsian journal of andrology
Differential expression of 5-alpha reductase isozymes in the prostate and its clinical implications.
Review in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04288427 (5-Alpha Reductase 2 as a Marker of Resistance to 5ARI Therapy), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
5-Alpha Reductase 2 as a Marker of Resistance to 5ARI Therapy
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- The gut-prostate axis in benign prostatic hyperplasia: systematic review of microbial dysbiosis and pathogenic mechanisms.BMC urology · 2026Pooled it
- Article
- A Multi-Target Phytotherapeutic Approach to Benign Prostatic Hyperplasia: Preclinical Characterization of a PhytoBPH-Mix.Nutrients · 2026Article
- Long-term use of dutasteride to treat androgenic alopecia in young men may lead to persistent abnormalities in semen parameters.Clinical and experimental reproductive medicine · 2025Article
- Risks and side effects in the medical management of benign prostatic hyperplasia.Prostate international · 2024Review
- Chickpea Sprouts as a Potential Dietary Support in Different Prostate Disorders-A Preliminary In Vitro Study.Molecules (Basel, Switzerland) · 2024Article
- Androgenetic alopecia: effects of oral finasteride on hormone profile, reproduction and sexual function.Endocrine · 2020Article
- Ethanol Extract ofNutrients · 2018Article
- Estrogens and Their Receptors in Prostate Cancer: Therapeutic Implications.Frontiers in oncology · 2018Review
- Article
- Anti-proliferative activities of finasteride in benign prostate epithelial cells require stromal fibroblasts and c-Jun gene.PloS one · 2017Article
- Differences in reproductive toxicology between alopecia drugs: an analysis on adverse events among female and male cases.Oncotarget · 2016Article
- Can glycoprofiling be helpful in detecting prostate cancer?Chemicke zvesti · 2015Article
- Methylated CpG dinucleotides in the 5-α reductase 2 gene may explain finasteride resistance in benign prostatic enlargement patients.Asian journal of andrologyArticle
- The intriguing role of fibroblasts andAsian journal of andrologyArticle
- Overview of the Molecular Steps in Steroidogenesis of the GABAergic Neurosteroids Allopregnanolone and Pregnanolone.Chronic stress (Thousand Oaks, Calif.)Review
- Autophagy: a stumbling block of androgen inhibition to treat benign prostatic hyperplasia or prostate cancer.Asian journal of andrologyArticle
- Phenotype variation among siblings with 5-alpha reductase deficiency: A case series.Indian journal of urology : IJU : journal of the Urological Society of IndiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of human benign or malignant prostatic diseases is closely associated with androgens, primarily testosterone (T) and dihydrotestosterone (DHT). T is converted to DHT by 5-alpha reductase (5-AR) isozymes. Differential expression of 5-AR isozymes is observed in both human benign and malignant prostatic tissues. 5-AR inhibitors (5-ARI) are commonly used for the treatment of benign prostatic hyperplasia (BPH) and were once promoted as chemopreventive agents for prostate cancer (PCa). This review discusses the role of the differential expression of 5-AR in the normal development of the human prostate and in the pathogenesis and progression of BPH and PCa.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.