Evidence map›Paper›PMID 24457826›Full record

ArticleChemical communications (Cambridge, England)2014

Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent.

Zhiliang Cheng, Ajlan Al Zaki, Ian W Jones, Henry K Hall, Craig A Aspinwall, Andrew Tsourkas

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zhiliang ChengDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. zcheng@seas.upenn.edu.
Ajlan Al Zaki
Ian W Jones
Henry K Hall
Craig A Aspinwall
Andrew Tsourkas
University of Arizona · USUniversity of Pennsylvania · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SHELLEY L BERGER · 1985 to 2026
$222.3M
Tumor-targeted Polymersomes to image and Treat Ovarian CancerR01CA175480 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CHENG, ZHILIANG · 2013 to 2017
$1.6M
Highly Paramagnetic, Biodegradable Nanoclusters for Imaging Prostate CancerR01CA157766 · NCI · UNIVERSITY OF PENNSYLVANIA · PI TSOURKAS, ANDREW · 2011 to 2015
$1.6M
Imaging B Cells with Gd-Labeled Dendrimer NanoclustersR01EB012065 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI TSOURKAS, ANDREW · 2010 to 2013
$1.4M
Stabilized Biomimetic Separation MediaR01GM095763 · NIGMS · UNIVERSITY OF ARIZONA · PI ASPINWALL, CRAIG A · 2011 to 2014
$1.1M
pH-responsive SPIOR21CA140695 · NCI · UNIVERSITY OF PENNSYLVANIA · PI TSOURKAS, ANDREW · 2009 to 2010
$381k
NCI NIH HHS 1R21CA140695NCI NIH HHS P30 CA016520NCI NIH HHS R01 CA157766NCI NIH HHS R01CA157766NCI NIH HHS R01 CA175480NCI NIH HHS R01CA175480NCI NIH HHS R21 CA140695NIBIB NIH HHS R01 EB012065NIBIB NIH HHS R01EB012065NIGMS NIH HHS GM095763NIGMS NIH HHS R01 GM095763
6 · The paper itself

Abstract

A highly efficient contrast agent for magnetic resonance imaging was developed by encapsulating gadolinium within a stabilized porous liposome. The highly porous membrane leads to a high relaxivity of the encapsulated Gd. The stability of the liposome was improved by forming a polymer network within the bilayer membrane.

Indexed as

Contrast MediaDextransFluorescein-5-isothiocyanateGadoliniumHeterocyclic CompoundsLiposomesMagnetic Resonance ImagingOrganometallic CompoundsPhosphatidylcholinesPorosity1,2-bis(10(2',4'-hexadienoyloxy)decanoyl)-sn-glycero-3-phosphocholineContrast MediaDextransFluorescein-5-isothiocyanatefluorescein isothiocyanate dextranGadoliniumgadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetateHeterocyclic CompoundsLiposomesOrganometallic CompoundsPhosphatidylcholines

Identifiers

PMID24457826
PMCPMC3947407
OpenAlexW2070415264

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.