ArticleCerebrovascular diseases (Basel, Switzerland)2014
Role of statin in atrial fibrillation-related stroke: an angiographic study for collateral flow.
Article in Cerebrovascular diseases (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Statin Effects in Atrial Fibrillation-Related Stroke: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2020Pooled it
- Guidelines for evaluation and management of cerebral collateral circulation in ischaemic stroke 2017.Stroke and vascular neurology · 2018Guideline
- Sanctuary sites in cortical stroke.Frontiers in neurology · 2025Article
- Diagnosis and Management of Atrial Fibrillation in Acute Ischemic Stroke in the Setting of Reperfusion Therapy: Insights and Strategies for Optimized Care.Journal of cardiovascular development and disease · 2023Review
- Statin Use and Stroke Rate in Older Adults With Atrial Fibrillation: A Population-Based Cohort Study.Journal of the American Heart Association · 2023Article
- Therapeutic Induction of Collateral Flow.Translational stroke research · 2023Review
- Efficacy of modified EDAS combined with a superficial temporal fascia attachment-dural reversal surgery for the precise treatment of ischemic cerebrovascular disease.Frontiers in surgery · 2023Review
- Effect of intravenous thrombolysis on core growth rate in patients with acute cerebral infarction.Frontiers in neurology · 2023Article
- Risk of Incident Epilepsy After a Middle Cerebral Artery Territory Infarction.Frontiers in neurology · 2022Article
- Association between Cerebrovascular Risk Factors and Collateral Compensation in Chronic Symptomatic Intracranial Vertebrobasilar Stenosis.European neurology · 2022Article
- Association of Systolic Blood Pressure and Cerebral Collateral Flow in Acute Ischemic Stroke by Stroke Subtype.Frontiers in neurology · 2022Article
- Collateral Status and Clinical Outcomes after Mechanical Thrombectomy in Patients with Anterior Circulation Occlusion.Journal of healthcare engineering · 2022Article
- Impact of Acute and Chronic Hypertension on Changes in Pial Collateral Tone In Vivo During Transient Ischemia.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Effect of Statin Therapy on Outcomes of Patients With Acute Ischemic Stroke and Atrial Fibrillation.Journal of the American Heart Association · 2019Article
- Low-dose statin pretreatment reduces stroke severity and improves functional outcomes.Journal of neurology · 2019Article
- Prestroke statins use reduces oxidized low density lipoprotein levels and improves clinical outcomes in patients with atrial fibrillation related acute ischemic stroke.BMC neurology · 2019Article
- Determining factors of better leptomeningeal collaterals: a study of 857 consecutive acute ischemic stroke patients.Journal of neurology · 2019Article
- Beneficial effects of pre-stroke statins use in cardioembolic stroke patients with atrial fibrillation: a hospital-based retrospective analysis.Archives of medical science : AMS · 2019Article
- Characteristics and Factors for Short-Term Functional Outcome in Stroke Patients With Atrial Fibrillation, Nationwide Retrospective Cohort Study.Frontiers in neurology · 2019Article
- Influence of statin therapy at time of stroke onset on functional outcome among patients with atrial fibrillation.International journal of cardiology · 2017Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundCurrently, intensive lipid lowering is recommended in patients with atherosclerotic ischemic stroke or transient ischemic attack. However, the role of statin in cardioembolic stroke is unclear. We investigated the association of statin with pretreatment collateral status in cardioembolic stroke.
methodsA collaborative study from two stroke centers in distinct geographic regions included consecutive patients with acute middle cerebral artery (MCA) infarction due to atrial fibrillation (AF) who underwent cerebral angiography. The relationship between pretreatment collateral grade and the use/dose of statin at stroke onset was assessed. The angiographic collateral grade was evaluated according to the ASITN/SIR Collateral Flow Grading System.
resultsNinety-eight patients (76 statin-naïve, 22 statin users) were included. Compared with statin-naïve patients, statin users were older and more frequently had hypertension, hyperlipidemia and coronary heart disease. Excellent collaterals (grade 3-4) were more frequently observed in statin users (11 patients, 50%) than in statin-naïve patients (21 patients, 27.6%; p = 0.049). The use of atorvastatin 10 mg equivalent or higher doses of statin was associated with excellent collaterals (p for trend = 0.025). In multiple regression analysis, prestroke statin use was independently associated with excellent collaterals (odds ratio, 7.841; 95% confidence interval, CI, 1.96-31.363; p = 0.004).
conclusionsPremorbid use of statin in AF patients is associated with excellent collateral flow. Although most statin trials excluded patients with cardioembolic stroke, our data suggests the possibility that statin may be beneficial in AF-related stroke
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.