Evidence map›Paper›PMID 24457421›Full record

Trial reportDevelopmental neuroscience2014

Improved frontoparietal white matter integrity in overweight children is associated with attendance at an after-school exercise program.

Cynthia E Krafft, David J Schaeffer, Nicolette F Schwarz, Lingxi Chi, Abby L Weinberger, Jordan E Pierce, Amanda L Rodrigue, Jerry D Allison, Nathan E Yanasak, Tianming Liu and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Developmental neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02227095 (Exercise & Overweight Children's Cognition), which is not on this map. Cited by 60 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02227095 nacompletednot on this map

Exercise & Overweight Children's Cognition

TypeinterventionalSponsorAugusta UniversityRan2008 to 2014Enrolled175ConditionsOverweight and ObesityArmsExercise, After-school program
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Review
  16. Article
  17. Structural and Functional Brain Changes in Children and Adolescents With Obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cynthia E KrafftDepartment of Psychology, University of Georgia, Athens, Ga., USA.
David J Schaeffer
Nicolette F Schwarz
Lingxi Chi
Abby L Weinberger
Jordan E Pierce
Amanda L Rodrigue
Jerry D Allison
Nathan E Yanasak
Tianming Liu
Catherine L Davis
Jennifer E McDowell

Funding

Exercise & Overweight Children's CognitionR01HL087923 · NHLBI · AUGUSTA UNIVERSITY · PI DAVIS, CATHERINE LUCY, MCDOWELL, JENNIFER E · 2008 to 2012
$5.2M
NHLBI NIH HHS R01 HL087923NHLBI NIH HHS R01 HL87923
6 · The paper itself

Abstract

Aerobic fitness is associated with white matter integrity (WMI) in adults as measured by diffusion tensor imaging (DTI). This study examined the effect of an 8-month exercise intervention on WMI in children. Participants were 18 sedentary, overweight (BMI≥85th percentile) 8- to 11-year-old children (94% Black), randomly assigned to either an aerobic exercise (n=10) or sedentary attention control group (n=8). Each group was offered an instructor-led after-school program every school day for approximately 8 months. Before and after the program, all subjects participated in DTI scans. Tractography was conducted to isolate the superior longitudinal fasciculus and investigate whether the exercise intervention affected WMI in this region. There was no group by time interaction for WMI in the superior longitudinal fasciculus. There was a group by time by attendance interaction, however, such that higher attendance at the exercise intervention, but not the control intervention, was associated with increased WMI. Heart rate and the total dose of exercise correlated with WMI changes in the exercise group. In the overall sample, increased WMI was associated with improved scores on a measure of attention and improved teacher ratings of executive function. This study indicates that participating in an exercise intervention improves WMI in children as compared to a sedentary after-school program.

Indexed as

ExerciseChildCognitionFemaleFrontal LobeHumansMaleNerve Fibers, MyelinatedNeuropsychological TestsOverweightParietal LobePhysical FitnessTreatment Outcome

Identifiers

PMID24457421
PMCPMC3995327

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.