ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2014
Maternal, fetal, and neonatal outcomes associated with measles during pregnancy: Namibia, 2009-2010.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 76 citations in OpenAlex.
- Measles and rubella: From global health challenges to advancements in molecular diagnostics in the elimination era.Molecular therapy. Nucleic acids · 2025Review
- Unmasking measles in pregnancy: A fatal rare case of maternal measles with posthumous diagnosis in a resource-constrained setting.Radiology case reports · 2025Article
- Congenital measles: A rare but life-threatening consequence of Canada's largest measles outbreak.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2025Article
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- Epidemiology, clinical overview, and potential risk of a new pandemic of measles virus.Infectious diseases & immunity · 2025Review
- Measles in pregnancy.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025Article
- On the Path to Measles and Rubella Elimination Following Rubella-Containing Vaccine Introduction, 2000-2023, Namibia.Vaccines · 2024Article
- Pregnant women and measles: we need to be vigilant during outbreaks.EClinicalMedicine · 2024Review
- Differential immunophenotype of circulating monocytes from pregnant women in response to viral ligands.BMC pregnancy and childbirth · 2023Article
- Updates on Measles Incidence and Eradication: Emphasis on the Immunological Aspects of Measles Infection.Medicina (Kaunas, Lithuania) · 2022Review
- Measles in a measles-eliminated country: A case report of a measles-infected postpartum mother and infant in Japan.IDCases · 2021Article
- Maternal-fetal infections: Why do they matter?Virulence · 2020Article
- Management guidelines for pregnant health care workers exposed to infectious dermatoses.International journal of women's dermatology · 2020Review
- Measles re-emerges and recommendation of vaccination.Journal of the Chinese Medical Association : JCMA · 2020Review
- Measles and Pregnancy: Immunity and Immunization-What Can Be Learned from Observing Complications during an Epidemic Year.Journal of pregnancy · 2020Article
- Dengue during pregnancy and live birth outcomes: a cohort of linked data from Brazil.BMJ open · 2019Article
- Dengue in pregnancy and maternal mortality: a cohort analysis using routine data.Scientific reports · 2018Article
- Monitoring the age-specificity of measles transmissions during 2009-2016 in Southern China.PloS one · 2018Article
- Immunization During Pregnancy: Impact on the Infant.Paediatric drugs · 2017Review
- Measles immunity among pregnant women aged 15-44 years in Namibia, 2008 and 2010.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2016Article
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12 authors at 3 institutions in 2 countries.
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Abstract
backgroundPrevious studies of maternal, fetal, and neonatal complications of measles during pregnancy suggest the possibility of increased risk for morbidity and mortality. In 2009-2011, a nationwide laboratory-confirmed measles outbreak occurred in Namibia, with 38% of reported cases among adults. This outbreak provided an opportunity to describe clinical features of measles in pregnant women and assess the relative risk for adverse maternal, fetal, and neonatal outcomes.
methodsA cohort of pregnant women with clinical measles was identified retrospectively from 6 district hospitals and clinics over a 12-month period. Each pregnant woman with measles was matched with 3 pregnant women without measles, randomly selected from antenatal clinic registers at the same hospital during the same time interval. We reviewed hospital and clinic records and conducted in-person interviews to collect demographic and clinical information on the pregnant women and their infants.
resultsOf 55 pregnant women with measles, 53 (96%) were hospitalized; measles-related complications included diarrhea (60%), pneumonia (40%), and encephalitis (5%). Among pregnant women with known human immunodeficiency virus (HIV) status, 15% of those without measles and 19% of those with measles were HIV positive. Of 42 measles-related pregnancies with known outcomes, 25 (60%) had ≥1 adverse maternal, fetal, or neonatal outcome and 5 women (12%) died. Compared with 172 pregnancies without measles, after adjusting for age, pregnancies with measles carried significantly increased risks for neonatal low birth weight (adjusted relative risk [aRR] = 3.5; 95% confidence interval [CI], 1.5-8.2), spontaneous abortion (aRR = 5.9; 95% CI, 1.8-19.7), intrauterine fetal death (aRR = 9.0; 95% CI, 1.2-65.5), and maternal death (aRR = 9.6; 95% CI, 1.3-70.0).
conclusionsOur findings suggest that measles virus infection during pregnancy confers a high risk of adverse maternal, fetal, and neonatal outcomes, including maternal death. Maximizing measles immunity among women of childbearing age would decrease the incidence of gestational measles and the attendant maternal, fetal, and neonatal morbidity and mortality.
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