Evidence map›Paper›PMID 24457285›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014

Impaired fear memory specificity associated with deficient endocannabinoid-dependent long-term plasticity.

Jonathan W Lovelace, Philip A Vieira, Alex Corches, Ken Mackie, Edward Korzus

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
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  4. Review
  5. Impairment of Synaptic Plasticity by Cannabis, ΔCold Spring Harbor perspectives in medicine · 2021
    Review
  6. Article
  7. Review
  8. Review
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  10. Article
  11. Article
  12. Article
  13. Prefrontal consolidation supports the attainment of fear memory accuracy.Learning & memory (Cold Spring Harbor, N.Y.) · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jonathan W LovelaceDepartment of Psychology and Neuroscience Program, University of California, Riverside, CA, USA.
Philip A VieiraDepartment of Psychology and Neuroscience Program, University of California, Riverside, CA, USA.
Alex CorchesBiomedical Sciences Program, University of California, Riverside, CA, USA.
Ken MackieDepartment of Psychological and Brain Sciences, Gill Center for Biomedical Sciences, Indiana University, Bloomington, IN, USA.
Edward Korzus1] Department of Psychology and Neuroscience Program, University of California, Riverside, CA, USA [2] Biomedical Sciences Program, University of California, Riverside, CA, USA.
University of California, Riverside · USIndiana University Bloomington · US

Funding

Neuronal cannabinoidsR01DA011322 · NIDA · UNIVERSITY OF WASHINGTON · PI MACKIE, KENNETH · 1998 to 2014
$3.4M
Cannabinoid Modulation of Cell FunctionK05DA021696 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI MACKIE, KENNETH · 2007 to 2017
$1.3M
Epigenetic Mechanisms in PsychosisR03MH086078 · NIMH · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI KORZUS, EDWARD · 2009 to 2010
$152k
NIDA NIH HHS DA011322NIDA NIH HHS DA021696NIDA NIH HHS K05 DA021696NIDA NIH HHS R01 DA011322NIMH NIH HHS MH086078NIMH NIH HHS R03 MH086078
6 · The paper itself

Abstract

In addition to its central role in learning and memory, N-methyl D-aspartate receptor (NMDAR)-dependent signaling regulates central glutamatergic synapse maturation and has been implicated in schizophrenia. We have transiently induced NMDAR hypofunction in infant mice during postnatal days 7-11, followed by testing fear memory specificity and presynaptic plasticity in the prefrontal cortex (PFC) in adult mice. We show that transient NMDAR hypofunction during early brain development, coinciding with the maturation of cortical plasticity results in a loss of an endocannabinoid (eCB)-mediated form of long-term depression (eCB-LTD) at adult central glutamatergic synapses, while another form of presynaptic long-term depression mediated by the metabotropic glutamate receptor 2/3 (mGluR2/3-LTD) remains intact. Mice with this selective impairment of presynaptic plasticity also showed deficits in fear memory specificity. The observed deficit in cortical presynaptic plasticity may represent a neural maladaptation contributing to network instability and abnormal cognitive functioning.

Indexed as

Amino AcidsAnimalsAnimals, NewbornBrainBridged Bicyclo Compounds, HeterocyclicConditioning, PsychologicalDisease Models, AnimalEndocannabinoidsEnzyme InhibitorsExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsFearFemaleLong-Term PotentiationLong-Term Synaptic DepressionMaleAmino AcidsBridged Bicyclo Compounds, HeterocyclicEndocannabinoidsEnzyme InhibitorsExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsLY 379268PhencyclidineReceptors, N-Methyl-D-Aspartate

Identifiers

PMID24457285
PMCPMC4023141
OpenAlexW2057751086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.