ArticleFEBS letters2014
Atrial fibrillation-associated connexin40 mutants make hemichannels and synergistically form gap junction channels with novel properties.
Article in FEBS letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function.Frontiers in physiology · 2019Article
- Functional Characterization of Novel Atrial Fibrillation-Linked GJA5 (Cx40) Mutants.International journal of molecular sciences · 2018Article
- Role of Non-Myocyte Gap Junctions and Connexin Hemichannels in Cardiovascular Health and Disease: Novel Therapeutic Targets?International journal of molecular sciences · 2018Review
- Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.Pharmacological reviews · 2017Review
- Regulation of cardiac gap junctions by protein phosphatases.Journal of molecular and cellular cardiology · 2017Review
- Altered conductance and permeability of Cx40 mutations associated with atrial fibrillation.The Journal of general physiology · 2015Article
- Diseases associated with leaky hemichannels.Frontiers in cellular neuroscience · 2015Review
- Connexin40 abnormalities and atrial fibrillation in the human heart.Journal of molecular and cellular cardiology · 2014Article
- Degradation of a connexin40 mutant linked to atrial fibrillation is accelerated.Journal of molecular and cellular cardiology · 2014Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Mutations of Cx40 (GJA5) have been identified in people with lone chronic atrial fibrillation including G38D and M163V which were found in the same patient. We used dual whole cell patch clamp procedures to examine the transjunctional voltage (Vj) gating and channel conductance properties of these two rare mutants. Each mutant exhibited slight alterations of Vj gating properties and increased the gap junction channel conductance (γj) by 20-30 pS. While co-expression of the two mutations had similar effects on Vj gating, it synergistically increased γj by 50%. Unlike WTCx40 or M163V, G38D induced activity of a dominant 271 pS hemichannel.
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Registered trials
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