ArticleDiagnostic pathology2014
Adrenal cortical neoplasms: a study of clinicopathological features related to epidermal growth factor receptor gene status.
Article in Diagnostic pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Is there a role for the IGF system and epidermal growth factor (EGF) in the pathogenesis of adrenocortical adenomas? A preliminary case-control study.Physiological research · 2020Article
- The role of epithelial growth factors and insulin growth factors in the adrenal neoplasms.Annals of translational medicine · 2018Review
- Myxoid adrenocortical adenoma with a pseudoglandular pattern: a case report and literature review.International journal of clinical and experimental pathology · 2017Article
- Review
- Roles of the pathologist in evaluating surrogate markers for medical therapy in adrenocortical carcinoma.Endocrine pathology · 2014Review
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Authors and funding
7 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAdrenocortical carcinoma (ACC) is a rare but highly malignant neoplasm with limited treatment options.
methodsIn this study, the clinicopathological features of 22 ACCs and 22 adrenocortical adenomas (ACA) were analyzed, and the EGFR protein expression, EGFR gene mutation status and EGFR gene copy number alteration of all tumors were examined using immunohistochemistry, fluorescence in situ hybridization (FISH), and the Scorpion Amplification Refractory Mutation System (ARMS), respectively.
resultsEGFR protein expression was detected in 63.6% of the ACC samples, and EGFR FISH was positive in 50% of the ACC samples (all were high polysomy on chromosome 7). In contrast, 27.3% of the ACA samples demonstrated EGFR expression, and none of the ACA samples tested positive by FISH. There were significant differences between the ACC and ACA in terms of protein expression (P = 0.035) and gene copy number alterations (P < 0.001).
conclusionsEGFR protein expression and high polysomy on chromosome 7 are frequent abnormalities in ACC than in ACA. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2068470757103500.
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