Trial reportTrials2014
An evaluation of the effectiveness of a multi-modal intervention in frail and pre-frail older people with type 2 diabetes--the MID-Frail study: study protocol for a randomised controlled trial.
Trial report in Trials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01654341 (A RANDOMIZED CLINICAL TRIAL TO EVALUATE THE EFFECTIVENESS OF A MULTI-MODAL INTERVENTION IN FRAIL AND PREFRAIL OLDER PEOPLE WITH TYPE 2 DIABETES ON FRAILTY AND QUALITY OF LIFE), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A RANDOMIZED CLINICAL TRIAL TO EVALUATE THE EFFECTIVENESS OF A MULTI-MODAL INTERVENTION IN FRAIL AND PREFRAIL OLDER PEOPLE WITH TYPE 2 DIABETES ON FRAILTY AND QUALITY OF LIFE: THE MID-Frail STUDY
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Diabetes Treatment in the Elderly: Incorporating Geriatrics, Technology, and Functional Medicine.Current diabetes reports · 2018Pooled it
- Long-term frailty and physical performance transitions in older people with type-2 diabetes. The MIDFRAIL randomized clinical study.The journal of nutrition, health & aging · 2025Trial
- Gait Speed and Evolution of Verbal Fluencies in Frail or Prefrail Older People with Type 2 Diabetes. A Pilot Study.The journal of nutrition, health & aging · 2021Trial
- Effectiveness of a multimodal intervention in functionally impaired older people with type 2 diabetes mellitus.Journal of cachexia, sarcopenia and muscle · 2019Trial
- Frailty and Brain-Muscle Correlates in Older People With Type 2 Diabetes: A structural-MRI Explorative Study.The journal of nutrition, health & aging · 2019Trial
- Scaling of an evidence-based intervention program in older people with diabetes and frailty in Latin America. Diabfrail-Latam clinical trial protocol.The Journal of frailty & aging · 2026Article
- Lifestyle interventions in older adults with type 2 diabetes mellitus: The key for healthy ageing.The journal of nutrition, health & aging · 2025Article
- Prevalence and Factors Associated with Sarcopenia in Post-Menopausal Women with Rheumatoid Arthritis.Mediterranean journal of rheumatology · 2024Article
- Characterizing Movement Patterns of Older Individuals with T2D in Free-Living Environments Using Wearable Accelerometers.Journal of clinical medicine · 2023Article
- Amino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE Studies.Metabolites · 2023Article
- Effect of Familial Longevity on Frailty and Sarcopenia: A Case-Control Study.International journal of environmental research and public health · 2023Observational
- A Therapeutic Vibrating Insole Device for Postural Instability in Older People with Type 2 Diabetes: A Randomized Control Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2022Article
- Article
- Telerehabilitation is Effective to Recover Functionality and Increase Skeletal Muscle Mass Index in COVID-19 Survivors.International journal of telerehabilitation · 2021Article
- The effect of oral glucose tolerance testing on changes in arterial stiffness and blood pressure in elderly women with hypertension and relationships between the stage of diabetes and physical fitness levels.Physical activity and nutrition · 2020Article
- Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study.Nutrients · 2020Article
- The Use of Posturography in Investigating the Risk of Falling in Frail or Prefrail Older People with Diabetes.The Journal of frailty & aging · 2020Observational
- Motivational Strategies to Prevent Frailty in Older Adults with Diabetes: A Focused Review.Journal of aging research · 2019Review
- Early-Onset Physical Frailty in Adults With Diabesity and Peripheral Neuropathy.Canadian journal of diabetes · 2018Article
- Interventions Against Disability in Frail Older Adults: Lessons Learned from Clinical Trials.The journal of nutrition, health & aging · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes, a highly prevalent, chronic disease, is associated with increasing frailty and functional decline in older people, with concomitant personal, social, and public health implications. We describe the rationale and methods of the multi-modal intervention in diabetes in frailty (MID-Frail) study. METHODS/
designThe MID-Frail study is an open, randomised, multicentre study, with random allocation by clusters (each trial site) to a usual care group or an intervention group. A total of 1,718 subjects will be randomised with each site enrolling on average 14 or 15 subjects. The primary objective of the study is to evaluate, in comparison with usual clinical practice, the effectiveness of a multi-modal intervention (specific clinical targets, education, diet, and resistance training exercise) in frail and pre-frail subjects aged ≥70 years with type 2 diabetes in terms of the difference in function 2 years post-randomisation. Difference in function will be measured by changes in a summary ordinal score on the short physical performance battery (SPPB) of at least one point. Secondary outcomes include daily activities, economic evaluation, and quality of life. DISCUSSION: The MID-Frail study will provide evidence on the clinical, functional, social, and economic impact of a multi-modal approach in frail and pre-frail older people with type 2 diabetes.
trial registrationClinicalTrials.gov: NCT01654341.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.