Evidence map›Paper›PMID 24456939›Full record

ReviewExpert reviews in molecular medicine2014

Advances in molecular biomarkers for gastric cancer: miRNAs as emerging novel cancer markers.

Hua-Hsi Wu, Wen-chang Lin, Kuo-Wang Tsai

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert reviews in molecular medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 2 syntheses or guidelines pooled it, 167 citations in OpenAlex.

  1. Pooled it
  2. Prognostic value of candidate microRNAs in gastric cancer: A validation study.Cancer biomarkers : section A of Disease markers · 2017
    Pooled it
  3. Article
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  6. Article
  7. Article
  8. Article
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  10. Article
  11. Significance of Serum Apelin Levels as a Biomarker for Gastric Cancer Diagnosis.Asian Pacific journal of cancer prevention : APJCP · 2023
    Article
  12. Up-regulation of collagen type V alpha 2 (Open medicine (Warsaw, Poland) · 2023
    Article
  13. Article
  14. Insights into the Relationship between Pentraxin-3 and Cancer.International journal of molecular sciences · 2022
    Review
  15. Article
  16. Article
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  19. Article
  20. Novel evidence for mBritish journal of cancer · 2022
    Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Hua-Hsi WuInstitute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan, Republic of China.
Wen-chang LinInstitute of Biomedical Informatics, National Yang-Ming University, Taipei 112, Taiwan, Republic of China.
Kuo-Wang TsaiDepartment of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan, Republic of China.
Institute of Biomedical Sciences, Academia Sinica · TWKaohsiung Veterans General Hospital · TWTaipei Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carcinoma of the stomach is one of the most prevalent cancer types in the world. Although the incidence of gastric cancer is declining, the outcomes of gastric cancer patients remain dismal because of the lack of effective biomarkers to detect early gastric cancer. Modern biomedical research has explored many potential gastric cancer biomarker genes by utilising serum protein antigens, oncogenic genes or gene families through improving molecular biological technologies, such as microarray, RNA-Seq and the like. Recently, the small noncoding microRNAs (miRNAs) have been suggested to be critical regulators in the oncogenesis pathways and to serve as useful clinical biomarkers. This new class of biomarkers is emerging as a novel molecule for cancer diagnosis and prognosis, including gastric cancer. By translational suppression of target genes, miRNAs play a significant role in the gastric cancer cell physiology and tumour progression. There are potential implications of previously discovered gastric cancer molecular biomarkers and their expression modulations by respective miRNAs. Therefore, many miRNAs are found to play oncogenic roles or tumour-suppressing functions in human cancers. With the surprising stability of miRNAs in tissues, serum or other body fluids, miRNAs have emerged as a new type of cancer biomarker with immeasurable clinical potential.

Indexed as

AdenocarcinomaBiomarkers, TumorGene Expression Regulation, NeoplasticHumansMicroRNAsPrognosisRNA InterferenceStomach NeoplasmsSystems BiologyBiomarkers, TumorMicroRNAs

Identifiers

PMID24456939
PMCPMC3908627
OpenAlexW2052277078

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.