Evidence map›Paper›PMID 24456692›Full record

ArticleLeukemia research2014

The AML1/ETO target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells.

Aitomi Essig, Jesus Duque-Afonso, Sven Schwemmers, Heike L Pahl, Michael Lübbert

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Aitomi EssigDepartment of Hematology and Oncology, University of Freiburg, Medical Center, Freiburg, Germany. Electronic address: aitomi.essig@charite.de.
Jesus Duque-AfonsoDepartment of Hematology and Oncology, University of Freiburg, Medical Center, Freiburg, Germany.
Sven SchwemmersDepartment of Hematology and Oncology, University of Freiburg, Medical Center, Freiburg, Germany.
Heike L PahlDepartment of Hematology and Oncology, University of Freiburg, Medical Center, Freiburg, Germany.
Michael LübbertDepartment of Hematology and Oncology, University of Freiburg, Medical Center, Freiburg, Germany.
University Medical Center Freiburg · DEUniversity of Freiburg · DE

Funding

Tissue BankP01CA108671 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Ronald Hoffman · 2006 to 2026
$82.0M
NCI NIH HHS P01 CA108671
6 · The paper itself

Abstract

The adaptor protein linker activator of T-cells 2 (LAT2) is a known AML1/ETO target gene whose function during normal hematopoiesis is unknown. We addressed the role of LAT2 during erythroid and myeloid differentiation of normal human CD34+ hematopoietic cells. LAT2 is expressed at low levels in CD34+ cells and upregulated during cytokine-induced myeloid and erythroid differentiation. Forced LAT2 expression leads to a delay of erythroid and myeloid differentiation keeping CD34+ cells in a more immature state, whereas LAT2 knockdown accelerates differentiation. It is tempting to speculate that by affecting the differentiation capacity of normal hematopoietic progenitors, LAT2 may contribute to the pathogenesis of AML.

Indexed as

Adaptor Proteins, Signal TransducingAntigens, CD34Cell DifferentiationCells, CulturedCore Binding Factor Alpha 2 SubunitGene Expression RegulationGranulocyte-Macrophage Colony-Stimulating FactorGranulocytesHematopoietic Stem CellsHumansInterleukin-3Leukocytes, MononuclearLymphocyte ActivationLymphocytesMonocytesProto-Oncogene ProteinsAdaptor Proteins, Signal TransducingAntigens, CD34Core Binding Factor Alpha 2 SubunitGranulocyte-Macrophage Colony-Stimulating FactorInterleukin-3LAT2 protein, humanProto-Oncogene ProteinsRNA, Small InterferingRUNX1 protein, humanRUNX1T1 protein, humanRUNX1 Translocation Partner 1 ProteinStem Cell FactorTranscription FactorsAcute myeloid leukemiaAdaptor moleculeErythroid differentiationMyeloid differentiation

Identifiers

PMID24456692
PMCPMC4135084
OpenAlexW2035259821

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.