Observational studyCritical care (London, England)2014
Application of heart-rate variability in patients undergoing weaning from mechanical ventilation.
Observational study in Critical care (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07771101 (Association Between Early Autonomic Dysfunction Measured by the Analgesia Nociception Index), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association Between Early Autonomic Dysfunction Measured by the Analgesia Nociception Index (ANI) and Prolonged Mechanical Ventilation in Postoperative ICU Patients
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Autonomic nervous system monitoring in intensive care as a prognostic tool. Systematic review.Revista Brasileira de terapia intensivaPooled it
- Early heart rate variability evaluation enables to predict ICU patients' outcome.Scientific reports · 2022Trial
- One-minute heart rate variability - an adjunct for airway obstruction identification.Physiological reports · 2019Trial
- Medication Effects on Heart Rate Variability in Critical Illness: The Overlooked Confounder.Critical care explorations · 2026Review
- Predictive value of resting energy expenditure and oxygen consumption of breathing for ventilator weaning in surgical intensive care patients in Viet Nam: a cross-sectional study.Acute and critical care · 2026Article
- Electromyographic Diaphragm and Electrocardiographic Signal Analysis for Weaning Outcome Classification in Mechanically Ventilated Patients.Sensors (Basel, Switzerland) · 2025Article
- Heart Rate Variability Applications in Medical Specialties: A Narrative Review.Applied psychophysiology and biofeedback · 2025Review
- Liberation from mechanical ventilation using Extubation Advisor Decision Support (LEADS): protocol for a multicentre pilot trial.BMJ open · 2025Article
- Heart Rate Variability During Weaning from Invasive Mechanical Ventilation: A Systematic Review.Journal of clinical medicine · 2024Review
- Predictors of weaning failure in ventilated intensive care patients: a systematic evidence map.Critical care (London, England) · 2024Review
- Defining predictors for successful mechanical ventilation weaning, using a data-mining process and artificial intelligence.Scientific reports · 2023Article
- Clinical surrogates of dysautonomia predict lethal outcome in COVID-19 on intensive care unit.Neurological research and practice · 2023Article
- Biosignal-Based Digital Biomarkers for Prediction of Ventilator Weaning Success.International journal of environmental research and public health · 2021Article
- Cardiopulmonary coupling indices to assess weaning readiness from mechanical ventilation.Scientific reports · 2021Article
- Observational
- A Personalized Signature and Chronotherapy-Based Platform for Improving the Efficacy of Sepsis Treatment.Frontiers in physiology · 2019Review
- Article
- Heart rate variability in critical care medicine: a systematic review.Intensive care medicine experimental · 2017Article
- The significance of circadian rhythms and dysrhythmias in critical illness.Journal of the Intensive Care Society · 2017Review
- Ventilator Weaning and Spontaneous Breathing Trials; an Educational Review.Emergency (Tehran, Iran) · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe process of weaning may impose cardiopulmonary stress on ventilated patients. Heart-rate variability (HRV), a noninvasive tool to characterize autonomic function and cardiorespiratory interaction, may be a promising modality to assess patient capability during the weaning process. We aimed to evaluate the association between HRV change and weaning outcomes in critically ill patients.
methodsThis study included 101 consecutive patients recovering from acute respiratory failure. Frequency-domain analysis, including very low frequency, low frequency, high frequency, and total power of HRV was assessed during a 1-hour spontaneous breathing trial (SBT) through a T-piece and after extubation after successful SBT.
resultsOf 101 patients, 24 (24%) had SBT failure, and HRV analysis in these patients showed a significant decrease in total power (P = 0.003); 77 patients passed SBT and were extubated, but 13 (17%) of them required reintubation within 72 hours. In successfully extubated patients, very low frequency and total power from SBT to postextubation significantly increased (P = 0.003 and P = 0.004, respectively). Instead, patients with extubation failure were unable to increase HRV after extubation.
conclusionsHRV responses differ between patients with different weaning outcomes. Measuring HRV change during the weaning process may help clinicians to predict weaning results and, in the end, to improve patient care and outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.