ArticleAllergy2014
Allergic airway diseases in a tropical urban environment are driven by dominant mono-specific sensitization against house dust mites.
Article in Allergy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 2 of them syntheses that pooled it.
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Who cites it
87 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Association between Migration and Prevalence of Allergic Diseases: A Systematic Review and Meta-Analysis.International archives of allergy and immunology · 2024Pooled it
- Risk factors of asthma in the Asian population: a systematic review and meta-analysis.Journal of physiological anthropology · 2021Pooled it
- Functional Genetic Variation in Ubiquitin D Promoter Influences Susceptibility to Atopic Dermatitis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- Evidence-to-Recommendation Framework for 2026 ACE Clinical Guideline on allergic rhinitis - diagnosis and management.Singapore medical journal · 2026Article
- Aquaporin 3 Promoter Polymorphisms Reduce Gene Expression and Associate Altered Autophagy-Related Gene Signatures With Atopic Dermatitis Susceptibility.Experimental dermatology · 2026Article
- Article
- Projecting the 20-year healthcare resource burden of asthma and COPD multimorbidity: insights from Singapore for integrated chronic respiratory care in South-East Asia.NPJ primary care respiratory medicine · 2026Article
- A Functional Variant ofJournal of asthma and allergy · 2026Article
- A narrative review of house dust mite allergy: species distribution and allergen sensitisation patterns across tropical regions.Frontiers in allergy · 2026Review
- Sensitization to Dog Dander Allergen Can f 1 is Associated with Asthma Symptom Severity and Exacerbations in a Singapore-Malaysia Cohort.Journal of asthma and allergy · 2026Article
- Profound Impact of Local Climatic Conditions on IgE Sensitization Profiles: Evidence from Argentine Cities.International journal of molecular sciences · 2025Article
- Examining the diagnostic validity of the ISAAC asthma questionnaire among participants from Singapore and Malaysia.Asia Pacific allergy · 2025Article
- Characterization of a major house dust mite allergen Der p 22 among Malaysian adult population.The World Allergy Organization journal · 2025Article
- Landscape of Aeroallergen Sensitization in Asia.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Review
- Associations Between Self-Reported Dietary Intake and Atopic Dermatitis Risk in Young Adults From Singapore and Malaysia.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Article
- Monitoring, distribution and clinical relevance of airborne pollen and fern spores in Southeast Asia - A systematic review.The World Allergy Organization journal · 2025Review
- Urticaria in China: incidence, prevalence, and disability-adjusted life years compared with G20 countries: findings from the Global Burden of Disease study 2021.Archives of dermatological research · 2025Article
- A Detailed Characterization of Asthma Manifestations and Their Associations with Dietary Intakes in a Singapore Cohort of Young Chinese Adults: A Cross-Sectional Study.Journal of asthma and allergy · 2025Article
- Functional Polymorphisms Regulate FOXO1 Transcript Expression and Contribute to the Risk and Symptom Severity of HDM-Induced Allergic Rhinitis.International archives of allergy and immunology · 2025Article
- Insights into Local Grass and Weed Pollen Sensitization in Bangkok, Thailand: IgE Reactivity Patterns, Cross-Reactivity, and Putative Allergens.Journal of asthma and allergy · 2025Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSoutheast Asian populations are increasingly affected by allergic airway diseases. Etiology and specific causes, however, are still unknown. The aim of this study is therefore to identify allergens and risk factors for the high prevalence of allergic airway disease in the tropical urban environment.
methodsSymptoms of allergic rhinitis (AR), asthma, and allergic dermatitis were recorded in two independent cohorts of 576 and 7373 ethnic Chinese individuals living in Singapore. Reactivity against common allergens was determined by skin prick tests (SPT); specific immunoglobulin E (sIgE) titers against 12 common allergens, as well as total serum IgE (tIgE), were measured in the smaller cohort.
resultsImmunoglobulin E sensitization was almost exclusively directed against house dust mite (HDM) allergens. More than 80% of individuals were HDM-sIgE positive. Of these, less than 30% also had sIgE for other allergens, and similarly, few of the HDM-sIgE-negative individuals reacted to other allergens. Titers for HDM-sIgE were 8-30 times higher than other non-HDM allergen titers and correlated directly with total serum tIgE levels. Migrants from nontropical countries typically arrived with low or undetectable HDM-sIgE but developed substantial titers in a time-dependent fashion. Importantly, prolonged stay in Singapore also resulted in the manifestation of AR and asthma symptoms, contributing to some of the highest national prevalence rates worldwide.
conclusionIn a tropical urban environment, the allergic response is dominated by a single allergen class. The mono-specific IgE sensitization against HDM translates into increased prevalence of allergic airway diseases, which now impact a large proportion of the population in Singapore.
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