ReviewJournal of diabetes research2013
Early life factors and type 2 diabetes mellitus.
Review in Journal of diabetes research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Malnutrition and type 2 diabetes mellitus across diverse global populations: a systematic review of observational evidence.Frontiers in clinical diabetes and healthcare · 2026Pooled it
- Pathophysiology of Type 2 Diabetes in Children and Adolescents.Current diabetes reviews · 2020Pooled it
- Age at menarche and the risk of gestational diabetes mellitus: a systematic review and meta-analysis.Endocrine · 2018Pooled it
- Prevalence of Gestational Diabetes Mellitus in Eastern and Southeastern Asia: A Systematic Review and Meta-Analysis.Journal of diabetes research · 2018Pooled it
- Early-life exposures, biological age acceleration, and type 2 diabetes in adulthood: mediation analyses in the UK Biobank.GeroScience · 2026Article
- Triglyceride-glucose index as predictor of gestational diabetes mellitus in early pregnancy: a prospective cohort study.Frontiers in endocrinology · 2026Article
- Inflammatory status along the brain-liver axis in animals vulnerable to prenatal stress: sex-related implications for stress-induced comorbidities.Translational psychiatry · 2025Article
- Birth weight and prematurity for predicting type 2 diabetes mellitus: a prognostic review.The Cochrane database of systematic reviews · 2025Article
- Characterizing the role of early life factors in machine learning-based multimorbidity risk prediction.PLOS digital health · 2025Article
- Economic Disadvantage During Childhood, Obesity, and Diabetes Across Three Birth Cohorts of Older Mexicans.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Review
- Clinical Profile, Risk Factors, and Complications in Young-Onset Type 2 Diabetes Mellitus.Cureus · 2024Article
- Prediabetes Prevalence by Adverse Social Determinants of Health in Adolescents.JAMA network open · 2024Article
- Challenges and pitfalls of youth-onset type 2 diabetes.World journal of diabetes · 2024Review
- GR/Ahi1 regulates WDR68-DYRK1A binding and mediates cognitive impairment in prenatally stressed offspring.Cellular and molecular life sciences : CMLS · 2024Article
- Less common forms of diabetes in young population.Pediatric endocrinology, diabetes, and metabolism · 2024Review
- Fetal Growth Trajectories and Measures of Insulin Resistance in Young Adults.The Journal of clinical endocrinology and metabolism · 2023Article
- Disparities in diabetes prevalence and management by race and ethnicity in the USA: defining a path forward.The lancet. Diabetes & endocrinology · 2023Review
- Fetal and neonatal dioxin exposure causes sex-specific metabolic alterations in mice.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Rho-kinase inhibition ameliorates non-alcoholic fatty liver disease in type 2 diabetic rats.Physiological research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes mellitus (T2DM) is a multifactorial disease, and its aetiology involves a complex interplay between genetic, epigenetic, and environmental factors. In recent years, evidences from both human and animal experiments have correlated early life factors with programming diabetes risk in adult life. Fetal and neonatal period is crucial for organ development. Many maternal factors during pregnancy may increase the risk of diabetes of offsprings in later life, which include malnutrition, healthy (hyperglycemia and obesity), behavior (smoking, drinking, and junk food diet), hormone administration, and even stress. In neonates, catch-up growth, lactation, glucocorticoids administration, and stress have all been found to increase the risk of insulin resistance or T2DM. Unfavorable environments (socioeconomic situation and famine) or obesity also has long-term negative effects on children by causing increased susceptibility to T2DM in adults. We also address the potential mechanisms that may underlie the developmental programming of T2DM. Therefore, it might be possible to prevent or delay the risk for T2DM by improving pre- and/or postnatal factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.