SynthesisBioMed research international2013
Sedation of newborn infants for the INSURE procedure, are we sure?
Synthesis in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 29 citations in OpenAlex.
- Propofol for endotracheal intubation in neonates: a dose-finding trial.Archives of disease in childhood. Fetal and neonatal edition · 2020Trial
- Improving LISA Practice: An Ongoing Observational Quality Improvement Initiative Following Initiation of Less-Invasive Surfactant Administration in a Level IV NICU.Children (Basel, Switzerland) · 2026Article
- Vikings, LISA and pain killers….Pediatric research · 2026Article
- Pharmacological therapy of neonatal analgosedation: current status, dilemmas, and perspectives.Frontiers in pediatrics · 2026Review
- Pre-Medications for Non-Emergency Tracheal Intubation in the United States Neonatal Intensive Care Units.Cureus · 2024Article
- A clinical study evaluating the combination of LISA and SNIPPV for the treatment of respiratory distress syndrome in preterm infants.Scientific reports · 2024Article
- Efficacy, Safety, and Usability of Remifentanil as Premedication for INSURE in Preterm Neonates.Children (Basel, Switzerland) · 2018Article
- Less invasive beractant administration in preterm infants: a pilot study.Clinics (Sao Paulo, Brazil) · 2016Article
- Predictors for an unsuccessful INtubation-SURfactant-Extubation procedure: a cohort study.BMC pediatrics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeonatal intubation is a stressful procedure that requires premedication to improve intubation conditions and reduce stress and adverse physiological responses. Premedication used during the INSURE (INtubation, SURfactant therapy, Extubation) procedure should have a very short duration of action with restoration of spontaneous breathing within a few minutes.
aimsTo determine the best sedative for intubation during the INSURE procedure by systematic review of the literature.
methodsWe reviewed all relevant studies reporting on premedication, distress, and time to restoration of spontaneous breathing during the INSURE procedure.
resultsThis review included 12 studies: two relatively small studies explicitly evaluated the effect of premedication (propofol and remifentanil) during the INSURE procedure, both showing good intubation conditions and an average extubation time of about 20 minutes. Ten studies reporting on fentanyl or morphine provided insufficient information about these items.
conclusionsToo little is known in the literature to draw a solid conclusion on which premedication could be best used during the INSURE procedure. Both remifentanil and propofol are suitable candidates but dose-finding studies to detect effective nontoxic doses in newborns with different gestational ages are necessary.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.