ArticleBioMed research international2013
Identification of age-related macular degeneration related genes by applying shortest path algorithm in protein-protein interaction network.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Identifying Choroidal Neovascularization-Associated Genes with GenePlexus in a Protein-Protein Interaction Network.Life (Basel, Switzerland) · 2026Article
- Unlocking the potential of flavonoid-infused drug delivery systems for diabetic wound healing with a mechanistic exploration.Inflammopharmacology · 2024Review
- Potential gene identification and pathway crosstalk analysis of age-related macular degeneration.Frontiers in genetics · 2022Article
- High Performance Computing Simulation of Intelligent Logistics Management Based on Shortest Path Algorithm.Computational intelligence and neuroscience · 2022Article
- C-CBL is required for inhibition of angiogenesis through modulating JAK2/STAT3 activity in ROP development.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020Article
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- Non-small-cell lung cancer pathological subtype-related gene selection and bioinformatics analysis based on gene expression profiles.Molecular and clinical oncology · 2018Article
- The Use of Protein-Protein Interactions for the Analysis of the Associations between PM2.5 and Some Diseases.BioMed research international · 2016Article
- Dissecting the Origin of Breast Cancer Subtype Stem Cell and the Potential Mechanism of Malignant Transformation.PloS one · 2016Article
- Article
- Article
- Identifying Novel Candidate Genes Related to Apoptosis from a Protein-Protein Interaction Network.Computational and mathematical methods in medicine · 2015Article
- Identification of novel thyroid cancer-related genes and chemicals using shortest path algorithm.BioMed research international · 2015Article
- Identifying gastric cancer related genes using the shortest path algorithm and protein-protein interaction network.BioMed research international · 2014Article
- A graphic method for identification of novel glioma related genes.BioMed research international · 2014Article
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Authors and funding
7 authors.
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Abstract
This study attempted to find novel age-related macular degeneration (AMD) related genes based on 36 known AMD genes. The well-known shortest path algorithm, Dijkstra's algorithm, was applied to find the shortest path connecting each pair of known AMD related genes in protein-protein interaction (PPI) network. The genes occurring in any shortest path were considered as candidate AMD related genes. As a result, 125 novel AMD genes were predicted. The further analysis based on betweenness and permutation test indicates that there are 10 genes involved in the formation or development of AMD and may be the actual AMD related genes with high probability. We hope that this contribution would promote the study of age-related macular degeneration and discovery of novel effective treatments.
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