Evidence map›Paper›PMID 24455682›Full record

ArticleBioMed research international2013

Efficacy of triptolide for children with moderately severe Henoch-Schönlein purpura nephritis presenting with nephrotic range proteinuria: a prospective and controlled study in China.

Li Wu, Jianhua Mao, Xia Jin, Haidong Fu, Huijun Shen, Jingjing Wang, Aimin Liu, Qiang Shu, Lizhong Du

Open access · hybridAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  6. Interventions for preventing and treating kidney disease in IgA vasculitis.The Cochrane database of systematic reviews · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Li WuDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China ; Department of Pediatrics, The Second People's Hospital of Linhai, Linhai, Zhejiang 317016, China.
Jianhua MaoDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.
Xia JinDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.
Haidong FuDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.
Huijun ShenDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.
Jingjing WangDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.
Aimin LiuDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.
Qiang ShuDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.
Lizhong DuDepartment of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.
Children's Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo observe the clinical efficacy of the Chinese herb, Triptolide, in children with moderately severe Henoch-Schönlein purpura nephritis (HSPN).

methodsFrom January 2007 to December 2011, 56 HSPN children manifested by nephrotic range proteinuria with normal kidney function and <50% crescents or sclerosing lesions on biopsy were hospitalized in the Children's Hospital of Zhejiang University School of Medicine. They were divided into two groups: the treatment group (n = 42; Triptolide at a dosage of 1 mg/kg · d, combined with prednisone at a dosage of 2 mg/kg · d, within a course of medium-to-long-term therapy of 6 to 9 months) and the control group (n = 14; prednisone alone, with the same procedure).

resultsShort-term remission was observed in 95% of patients from treatment group and in 72% of patients from control group, respectively. There was a significant difference between both groups (χ(2) = 6.222, P = 0.029) for short-term effects. Meanwhile, no significant difference, as proteinuria, hematuria, hypertension, and decreased eGFR, was observed between the two groups in long-term followup (χ(2) = 3.111, P = 0.097). The Kaplan-Meier plot analysis also revealed no significant difference (χ(2) = 2.633, P = 0.105).

conclusionTriptolide is effective in relieving short-term symptoms for moderately severe HSPN children, though its long-term effects need to be observed further.

Indexed as

BiopsyChildChild, PreschoolChinaDiterpenesDrugs, Chinese HerbalEpoxy CompoundsFemaleHumansIgA VasculitisKaplan-Meier EstimateMaleNephritisPhenanthrenesProteinuriaDiterpenesDrugs, Chinese HerbalEpoxy CompoundsPhenanthrenestriptolide

Identifiers

PMID24455682
PMCPMC3878807
OpenAlexW1987880803

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.