ArticleSouth Asian journal of cancer2013
Procalcitonin and quantitative C-reactive protein role in the early diagnosis of sepsis in patients with febrile neutropenia.
Article in South Asian journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Management of infection and febrile neutropenia in patients with solid cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016Guideline
- C-reactive protein in adult sepsis: systematic review and meta-analysis.Clinics (Sao Paulo, Brazil) · 2025Review
- Procalcitonin and qSOFA as a Marker of Mortality in Sepsis.Reviews on recent clinical trials · 2024Observational
- Performance Comparison of Procalcitonin, Delta Neutrophil Index, C-Reactive Protein, and Serum Amyloid A Levels in Patients with Hematologic Diseases.Diagnostics (Basel, Switzerland) · 2023Article
- Article
- Utility of procalcitonin as a predictor of bloodstream infections and supportive modality requirements in critically ill cancer patients.Clinica chimica acta; international journal of clinical chemistry · 2020Article
- Procalcitonin and C-Reactive Protein As Markers of Bacteremia in Patients With Febrile Neutropenia Who Receive Chemotherapy for Acute Leukemia: A Prospective Study From Nepal.Journal of global oncology · 2019Article
- Time-resolved fluorescent immunoassay-based combined detection of procalcitonin, C-reactive protein, heparin binding protein, and serum amyloid A1 to improve the diagnostic accuracy of early infection.Journal of clinical laboratory analysis · 2019Article
- Combination of procalcitonin, C-reaction protein and carcinoembryonic antigens for discriminating between benign and malignant pleural effusions.Oncology letters · 2018Article
- Review
- Procalcitonin: present and future.Irish journal of medical science · 2015Review
- Blood Procalcitonin Predicts Spontaneous Bacterial Peritonitis in Patients with Cirrhosis and Ascites.Middle East journal of digestive diseases · 2015Article
- Biomarkers for the diagnosis of bacterial infections: in pursuit of the 'Holy Grail'.The Indian journal of medical research · 2015Article
- Immunocompromised hosts: Infections and biomarkers.South Asian journal of cancer · 2013Article
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4 authors.
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Abstract
backgroundNeutropenia with fever is a common syndrome in patients with hematologic malignancies who have a high risk of infectious diseases. As early diagnosis of infection in such patients is really important, the aim of this study was to investigate the sensitivity and specificity of procalcitonin (PCT) and C-reactive protein (CRP) in the diagnosis of sepsis in febrile neutropenic patients in a referral malignant care center of Isfahan in 2010-2011. MATERIALS AND
methodsIn this analytical cross-sectional study, all the febrile neutropenic patients who were admitted in the referral malignant care center in 2010-2011 were evaluated. The data from every individual, including sex, age, admission time, and duration of fever before taking antibiotics were collected. Sixty-four subjects were involved in the study. Blood samples of the subjects were obtained and the levels of PCT, CRP, Absolute neutrophil count (ANC), and white blood cell count were measured, and blood cultures were obtained. According to the test results, the 64 subjects were divided into two groups including patients with sepsis and without sepsis.
resultsMean value of PCT in the sepsis group was 28.65 ± 2.68 and in the non-sepsis group was 2.48 ± 0.66, with a P value of 0.000. In case of CRP, the sepsis group had a mean of 159.48 ± 9.73 and the non-sepsis group had a mean of 126.17 ± 10.63 (P = 0.015). Sensitivity and specificity were analyzed by using receiver operating characteristic (ROC) curve and were found to be 92.5% and 97.3%, respectively, for PCT and 70.5% and 42.1%, respectively, for CRP.
conclusionPCT can be considered as a predictive factor and a diagnostic marker for the diagnosis of sepsis in febrile neutropenic patients.
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