ArticleBeilstein journal of nanotechnology2013
Cytotoxic and proinflammatory effects of PVP-coated silver nanoparticles after intratracheal instillation in rats.
Article in Beilstein journal of nanotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
- Review
- Nanoparticles and Antiviral Vaccines.Vaccines · 2023Review
- Accumulation and Effect of Silver Nanoparticles Functionalized withNanomaterials (Basel, Switzerland) · 2021Article
- Silver nanoparticles and silver ions cause inflammatory response through induction of cell necrosis and the release of mitochondria in vivo and in vitro.Cell biology and toxicology · 2021Article
- Biodistribution and pulmonary metabolic effects of silver nanoparticles in mice following acute intratracheal instillations.Environmental science and pollution research international · 2021Article
- Assessment of Cytokine-Induced Neutrophil Chemoattractants as Biomarkers for Prediction of Pulmonary Toxicity of Nanomaterials.Nanomaterials (Basel, Switzerland) · 2020Article
- Antibacterial magnetic nanoparticles for therapeutics: a review.IET nanobiotechnology · 2019Review
- Antiviral and Immunomodulatory Activity of Silver Nanoparticles in Experimental RSV Infection.Viruses · 2019Article
- Synthesis of biogenic silver nanoparticles using Althaea officinalis as reducing agent: evaluation of toxicity and ecotoxicity.Scientific reports · 2018Article
- Hazard Screening Methods for Nanomaterials: A Comparative Study.International journal of molecular sciences · 2018Article
- Pro-Inflammatory versus Immunomodulatory Effects of Silver Nanoparticles in the Lung: The Critical Role of Dose, Size and Surface Modification.Nanomaterials (Basel, Switzerland) · 2017Article
- Impact of pulmonary exposure to gold core silver nanoparticles of different size and capping agents on cardiovascular injury.Particle and fibre toxicology · 2016Article
- Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague-Dawley rats.Respiratory research · 2016Article
- A novel covalent approach to bio-conjugate silver coated single walled carbon nanotubes with antimicrobial peptide.Journal of nanobiotechnology · 2016Article
- Aerosolized Silver Nanoparticles in the Rat Lung and Pulmonary Responses over Time.Toxicologic pathology · 2016Article
- Cardiac Ischemia Reperfusion Injury Following Instillation of 20 nm Citrate-capped Nanosilver.Journal of nanomedicine & nanotechnology · 2015Article
- Novel pegylated silver coated carbon nanotubes kill Salmonella but they are non-toxic to eukaryotic cells.Journal of nanobiotechnology · 2015Article
- Pulmonary effects of silver nanoparticle size, coating, and dose over time upon intratracheal instillation.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- Pulmonary toxicity of instilled silver nanoparticles: influence of size, coating and rat strain.PloS one · 2015Article
- Acute inflammatory responses of nanoparticles in an intra-tracheal instillation rat model.PloS one · 2015Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silver nanoparticles (AgNP) are among the most promising nanomaterials, and their usage in medical applications and consumer products is growing rapidly. To evaluate possible adverse health effects, especially to the lungs, the current study focused on the cytotoxic and proinflammatory effects of AgNP after the intratracheal instillation in rats. Monodisperse, PVP-coated AgNP (70 nm) showing little agglomeration in aqueous suspension were instilled intratracheally. After 24 hours, the lungs were lavaged, and lactate dehydrogenase (LDH), total protein, and cytokine levels as well as total and differential cell counts were measured in the bronchoalveolar lavage fluid (BALF). Instillation of 50 µg PVP-AgNP did not result in elevated LDH, total protein, or cytokine levels in BALF compared to the control, whereas instillation of 250 µg PVP-AgNP caused a significant increase in LDH (1.9-fold) and total protein (1.3-fold) levels as well as in neutrophil numbers (60-fold) of BALF. Furthermore, while there was no change in BALF cytokine levels after the instillation of 50 µg PVP-AgNP, instillation of 250 µg PVP-AgNP resulted in significantly increased levels of seven out of eleven measured cytokines. These finding suggest that exposure to inhaled AgNP can induce moderate pulmonary toxicity, but only at rather high concentrations.
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