Evidence map›Paper›PMID 24455420›Full record

ReviewISRN inflammation2013

Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines.

Kassem Makki, Philippe Froguel, Isabelle Wolowczuk

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ISRN inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05349227 (Comprehensive Outcomes for After Cancer Health), which is not on this map. Cited by 568 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
568citing papers in PubMed, 10 pooled it
29.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05349227 narecruitingnot on this mapstarted 2022, after this paper: background citation

Comprehensive Outcomes for After Cancer Health (COACH): the Feasibility and Impact of an MHealth Augmented Coaching Program for Self-Management in Cancer Survivors

TypeinterventionalSponsorPack HealthRan2022 to 2027Enrolled625ConditionsOvarian Cancer, Breast Cancer, Lung Cancer, Gastric CancerArmsDigital Health Coaching Program, Fitbit
3 · Its place in the literature

Who cites it

568 citing papers in PubMed, 10 syntheses or guidelines pooled it, 1,059 citations in OpenAlex.

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  11. Plant-DerivedNutrients · 2022
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508 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kassem MakkiCentre National de la Recherche Scientifique, UMR8199, Lille Pasteur Institute, BP 245, 59019 Lille, France ; University Lille II, 59800 Lille, France.
Philippe FroguelCentre National de la Recherche Scientifique, UMR8199, Lille Pasteur Institute, BP 245, 59019 Lille, France ; University Lille II, 59800 Lille, France.
Isabelle WolowczukCentre National de la Recherche Scientifique, UMR8199, Lille Pasteur Institute, BP 245, 59019 Lille, France ; University Lille II, 59800 Lille, France.
Université de Lille · FRInstitut Pasteur de Lille · FR

Funding

Medical Research Council G1002084
6 · The paper itself

Abstract

Adipose tissue is a complex organ that comprises a wide range of cell types with diverse energy storage, metabolic regulation, and neuroendocrine and immune functions. Because it contains various immune cells, either adaptive (B and T lymphocytes; such as regulatory T cells) or innate (mostly macrophages and, more recently identified, myeloid-derived suppressor cells), the adipose tissue is now considered as a bona fide immune organ, at the cross-road between metabolism and immunity. Adipose tissue disorders, such as those encountered in obesity and lipodystrophy, cause alterations to adipose tissue distribution and function with broad effects on cytokine, chemokine, and hormone expression, on lipid storage, and on the composition of adipose-resident immune cell populations. The resulting changes appear to induce profound consequences for basal systemic inflammation and insulin sensitivity. The purpose of this review is to synthesize the current literature on adipose cell composition remodeling in obesity, which shows how adipose-resident immune cells regulate inflammation and insulin resistance-notably through cytokine and chemokine secretion-and highlights major research questions in the field.

Identifiers

PMID24455420
PMCPMC3881510
OpenAlexW2010139869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.