Evidence map›Paper›PMID 24455213›Full record

ArticleJournal of obesity2013

Association of obesity with proteasomal gene polymorphisms in children.

Sarmite Kupca, Tatjana Sjakste, Natalija Paramonova, Olga Sugoka, Irena Rinkuza, Ilva Trapina, Ilva Daugule, Alfred J Sipols, Ingrida Rumba-Rozenfelde

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of obesity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Index of orthodontic treatment need in obese adolescents.International journal of dentistry · 2015
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sarmite KupcaFaculty of Medicine, University of Latvia, Sarlotes Street 1a, Riga 1001, Latvia ; Institute of Biology, University of Latvia, Miera Street 3, Salaspils 2169, Latvia ; Institute of Experimental and Clinical Medicine, University of Latvia, No. 4 Ojara Vaciesa Street, Riga 1004, Latvia.
Tatjana SjaksteInstitute of Biology, University of Latvia, Miera Street 3, Salaspils 2169, Latvia.
Natalija ParamonovaInstitute of Biology, University of Latvia, Miera Street 3, Salaspils 2169, Latvia.
Olga SugokaInstitute of Biology, University of Latvia, Miera Street 3, Salaspils 2169, Latvia.
Irena RinkuzaFaculty of Medicine, University of Latvia, Sarlotes Street 1a, Riga 1001, Latvia.
Ilva TrapinaFaculty of Medicine, University of Latvia, Sarlotes Street 1a, Riga 1001, Latvia ; Institute of Biology, University of Latvia, Miera Street 3, Salaspils 2169, Latvia.
Ilva DauguleFaculty of Medicine, University of Latvia, Sarlotes Street 1a, Riga 1001, Latvia.
Alfred J SipolsFaculty of Medicine, University of Latvia, Sarlotes Street 1a, Riga 1001, Latvia ; Institute of Experimental and Clinical Medicine, University of Latvia, No. 4 Ojara Vaciesa Street, Riga 1004, Latvia.
Ingrida Rumba-RozenfeldeFaculty of Medicine, University of Latvia, Sarlotes Street 1a, Riga 1001, Latvia.
University of Latvia · LV

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to ascertain possible associations between childhood obesity, its anthropometric and clinical parameters, and three loci of proteasomal genes rs2277460 (PSMA6 c.-110C>A), rs1048990 (PSMA6 c.-8C>G), and rs2348071 (PSMA3 c. 543+138G>A) implicated in obesity-related diseases. Obese subjects included 94 otherwise healthy children in Latvia. Loci were genotyped and then analyzed using polymerase chain reactions, with results compared to those of 191 nonobese controls. PSMA3 SNP frequency differences between obese children and controls, while not reaching significance, suggested a trend. These differences, however, proved highly significant (P < 0.002) in the subset of children reporting a family history of obesity. Among obese children denying such history, PSMA6 c.-8C>G SNP differences, while being nonsignificant, likewise suggested a trend in comparison to the nonobese controls. No PSMA6 c.-110C>A SNP differences were detected in the obese group or its subsets. Finally, PSMA3 SNP differences were significantly associated (P < 0.05) with circulating low-density lipoprotein cholesterol (LDL) levels. Our results clearly implicate the PSMA3 gene locus as an obesity risk factor in those Latvian children with a family history of obesity. While being speculative, the clinical results are suggestive of altered circulatory LDL levels playing a possible role in the etiology of obesity in the young.

Indexed as

Polymorphism, Single NucleotideAdolescentAnalysis of VarianceBlood GlucoseBlood PressureBody Mass IndexCase-Control StudiesChildChild, PreschoolCholesterol, LDLFemaleGenetic Predisposition to DiseaseGenotypeHumansMalePediatric ObesityBlood GlucoseCholesterol, LDLProteasome Endopeptidase ComplexPSMA3 protein, humanPSMA6 protein, human

Identifiers

PMID24455213
PMCPMC3880696
OpenAlexW2032025438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.