Evidence map›Paper›PMID 24455188›Full record

ArticleActa naturae2013

Polyreactive monoclonal autoantibodies in multiple sclerosis: functional selection from phage display library and characterization by deep sequencing analysis.

Y A Lomakin, M Yu Zakharova, A A Belogurov, N A Bykova, M A Dronina, A E Tupikin, V D Knorre, A N Boyko, A V Favorov, M R Kabilov and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC
In one paragraph

Article in Acta naturae, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Y A LomakinShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia.
M Yu ZakharovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia.
A A BelogurovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia ; Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia.
N A BykovaKharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, 127994, Moscow, Russia ; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991, Moscow, Russia.
M A DroninaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia.
A E TupikinInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia ; Genomics Core Facility, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia.
V D KnorreShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia.
A N BoykoMoscow Multiple Sclerosis Center at the City Hospital #11, 127018, Moscow, Russia ; Pirogov Russian National Research Medical University, Department of Fundamental and Clinical Neurology and Neurosurgery, 117997, Moscow, Russia.
A V FavorovVavilov Institute of General Genetics, Russian Academy of Sciences, 119991, Moscow, Russia ; Department of Oncology, Division of Biostatistics and Bioinformatics, Johns Hopkins University School of Medicine, 21218, Baltimore, Maryland, USA ; State Research Institute of Genetics and Selection of Industrial Microorganisms GosNIIGenetika, 117545, Moscow, Russia.
M R KabilovInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia ; Genomics Core Facility, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia.
N A PonomarenkoShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia.
Gabibov GabibovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia ; Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia ; Faculty of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
Institute of Bioorganic Chemistry · RULomonosov Moscow State University · RURussian Academy of Sciences · RUJohns Hopkins University · USPirogov Russian National Research Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system that primarily affects young and middle-aged people. It is widely accepted that B lymphocyte activation is required for MS progression. Despite the fact that the exact triggering mechanisms of MS remain enigmatic, one may suggest that MS can be induced by viral or bacterial infection in combination with specific genetic and environmental factors. Using deep sequencing and functional selection methodologies we characterized clones of poly- and cross-reactive antibodies that are capable of simultaneous recognition of viral proteins and autoantigens. The latter, in turn, possibly may trigger MS progression through molecular mimicry. It was identified that two cross-reactive antigens are probably recognized by light or heavy chains individually. According to the high structural homology between selected autoantibodies and a number of various antiviral IgGs, we suggest that a wide range of pathogens, instead of a single virus, be regarded as possible triggers of MS.

Indexed as

autoreactive B cellscross-reactivitydeep sequencingMultiple sclerosismyelin basic proteinviral triggers

Identifiers

PMID24455188
PMCPMC3890994
OpenAlexW95065582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.