ArticlePloS one2014
Independently outgrowing neurons and geometry-based synapse formation produce networks with realistic synaptic connectivity.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 31 citations in OpenAlex.
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- Relation between palm and finger cortical representations in primary somatosensory cortex: A 7T fMRI study.Human brain mapping · 2021Article
- How neurons exploit fractal geometry to optimize their network connectivity.Scientific reports · 2021Article
- BCNNM: A Framework forFrontiers in computational neuroscience · 2020Article
- Theoretical Models of Neural Development.iScience · 2018Review
- And yet it moves: Recovery of volitional control after spinal cord injury.Progress in neurobiology · 2018Review
- The antipsychotic drugs olanzapine and haloperidol modify network connectivity and spontaneous activity of neural networks in vitro.Scientific reports · 2017Article
- Spag6 Negatively Regulates Neuronal Migration During Mouse Brain Development.Journal of molecular neuroscience : MN · 2015Article
- Developmental time windows for axon growth influence neuronal network topology.Biological cybernetics · 2015Article
- An algorithm to predict the connectome of neural microcircuits.Frontiers in computational neuroscience · 2015Article
- Homeostatic structural plasticity increases the efficiency of small-world networks.Frontiers in synaptic neuroscience · 2014Article
- Context-aware modeling of neuronal morphologies.Frontiers in neuroanatomy · 2014Article
- Axonal and dendritic density field estimation from incomplete single-slice neuronal reconstructions.Frontiers in neuroanatomy · 2014Article
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Authors and funding
8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Neuronal signal integration and information processing in cortical networks critically depend on the organization of synaptic connectivity. During development, neurons can form synaptic connections when their axonal and dendritic arborizations come within close proximity of each other. Although many signaling cues are thought to be involved in guiding neuronal extensions, the extent to which accidental appositions between axons and dendrites can already account for synaptic connectivity remains unclear. To investigate this, we generated a local network of cortical L2/3 neurons that grew out independently of each other and that were not guided by any extracellular cues. Synapses were formed when axonal and dendritic branches came by chance within a threshold distance of each other. Despite the absence of guidance cues, we found that the emerging synaptic connectivity showed a good agreement with available experimental data on spatial locations of synapses on dendrites and axons, number of synapses by which neurons are connected, connection probability between neurons, distance between connected neurons, and pattern of synaptic connectivity. The connectivity pattern had a small-world topology but was not scale free. Together, our results suggest that baseline synaptic connectivity in local cortical circuits may largely result from accidentally overlapping axonal and dendritic branches of independently outgrowing neurons.
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