ArticlePloS one2014
Hindlimb suspension and SPE-like radiation impairs clearance of bacterial infections.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
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- Synergistic interplay between radiation and microgravity in spaceflight-related immunological health risks.Immunity & ageing : I & A · 2024Review
- The Impact of Microgravity on Immunological States.ImmunoHorizons · 2023Review
- Sleep and Core Body Temperature Alterations Induced by Space Radiation in Rats.Life (Basel, Switzerland) · 2023Article
- Cardiovascular, Lymphatic, and Ocular Health in Space.Life (Basel, Switzerland) · 2022Review
- The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2021Article
- Beyond Low-Earth Orbit: Characterizing Immune and microRNA Differentials following Simulated Deep Spaceflight Conditions in Mice.iScience · 2020Article
- How does spaceflight affect the acquired immune system?NPJ microgravity · 2020Review
- Combined Effects of Low-Dose Proton Radiation and Simulated Microgravity on the Mouse Retina and the Hematopoietic System.Radiation research · 2019Article
- Limitations in predicting the space radiation health risk for exploration astronauts.NPJ microgravity · 2018Review
- Changes in the distribution and function of leukocytes after whole-body iron ion irradiation.Journal of radiation research · 2016Article
- A reproducible radiation delivery method for unanesthetized rodents during periods of hind limb unloading.Life sciences in space research · 2015Article
- Effects of a granulocyte colony stimulating factor, Neulasta, in mini pigs exposed to total body proton irradiation.Life sciences in space research · 2015Article
- Article
- Evidence of Disseminated Intravascular Coagulation in a Porcine Model Following Radiation Exposure.Life sciences in space research · 2014Article
- Space Radiation: The Number One Risk to Astronaut Health beyond Low Earth Orbit.Life (Basel, Switzerland) · 2014Review
- Biological Effects of Space Radiation and Development of Effective Countermeasures.Life sciences in space research · 2014Article
- Ionizing radiation selectively reduces skin regulatory T cells and alters immune function.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major risk of extended space travel is the combined effects of weightlessness and radiation exposure on the immune system. In this study, we used the hindlimb suspension model of microgravity that includes the other space stressors, situational and confinement stress and alterations in food intake, and solar particle event (SPE)-like radiation to measure the combined effects on the ability to control bacterial infections. A massive increase in morbidity and decrease in the ability to control bacterial growth was observed using 2 different types of bacteria delivered by systemic and pulmonary routes in 3 different strains of mice. These data suggest that an astronaut exposed to a strong SPE during extended space travel is at increased risk for the development of infections that could potentially be severe and interfere with mission success and astronaut health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.