ArticlePloS one2014
Paternally expressed, imprinted insulin-like growth factor-2 in chorionic villi correlates significantly with birth weight.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- The influence of acculturation on the risk of preterm birth and low birthweight in migrant women residing in Western Australia.PloS one · 2023Article
- Insights to maternal regulation of the paternal genome in mammalian livestock embryos: A mini-review.Frontiers in genetics · 2022Review
- Developmental origins of metabolic diseases.Physiological reviews · 2021Review
- Detection of selection signatures for response to Aleutian mink disease virus infection in American mink.Scientific reports · 2021Article
- The relationship between IGF-I and -II concentrations and body composition at birth and over the first 2 months.Pediatric research · 2019Article
- Article
- Effects of maternal nutrition on the expression of genomic imprinted genes in ovine fetuses.Epigenetics · 2018Article
- Breast cancer protection by genomic imprinting in close kin families.BMC medical genetics · 2017Review
- Human relaxins (RLNH1, RLNH2), their receptor (RXFP1) and fetoplacental growth.Reproduction (Cambridge, England) · 2017Article
- Mechanistic Insight into Long Noncoding RNAs and the Placenta.International journal of molecular sciences · 2017Review
- A new biological and clinical resource for research into pregnancy complications: The Baby Bio Bank.Placenta · 2016Article
- Lentivirus-mediated PHLDA2 overexpression inhibits trophoblast proliferation, migration and invasion, and induces apoptosis.International journal of molecular medicine · 2016Article
- Epigenetic Characterization of CDKN1C in Placenta Samples from Non-syndromic Intrauterine Growth Restriction.Frontiers in genetics · 2016Article
- Placental expression of imprinted genes varies with sampling site and mode of delivery.Placenta · 2015Article
- GLI3 Links Environmental Arsenic Exposure and Human Fetal Growth.EBioMedicine · 2015Article
- Relationships of maternal and paternal anthropometry with neonatal body size, proportions and adiposity in an Australian cohort.American journal of physical anthropology · 2015Article
- The role and interaction of imprinted genes in human fetal growth.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Placental 5-methylcytosine and 5-hydroxymethylcytosine patterns associate with size at birth.Epigenetics · 2015Article
- Article
- Genomic imprinting in human placentation.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
contextFetal growth involves highly complex molecular pathways. IGF2 is a key paternally expressed growth hormone that is critical for in utero growth in mice. Its role in human fetal growth has remained ambiguous, as it has only been studied in term tissues. Conversely the maternally expressed growth suppressor, PHLDA2, has a significant negative correlation between its term placental expression and birth weight.
objectiveThe aim of this study is to address the role in early gestation of expression of IGF1, IGF2, their receptors IGF1R and IGF2R, and PHLDA2 on term birth weight.
designReal-time quantitative PCR was used to investigate mRNA expression of IGF1, IGF2, IGF1R, IGF2R and PHLDA2 in chorionic villus samples (CVS) (n = 260) collected at 11-13 weeks' gestation. Expression was correlated with term birth weight using statistical package R including correction for several confounding factors.
resultsTranscript levels of IGF2 and IGF2R revealed a significant positive correlation with birth weight (0.009 and 0.04, respectively). No effect was observed for IGF1, IGF1R or PHLDA2 and birth weight. Critically, small for gestational age (SGA) neonates had significantly lower IGF2 levels than appropriate for gestational age neonates (p = 3.6 × 10(-7)).
interpretationOur findings show that IGF2 mRNA levels at 12 weeks gestation could provide a useful predictor of future fetal growth to term, potentially predicting SGA babies. SGA babies are known to be at a higher risk for type 2 diabetes. This research reveals an imprinted, parentally driven rheostat for in utero growth.
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