Evidence map›Paper›PMID 24454832›Full record

ArticlePloS one2014

End criteria for reaching maximal oxygen uptake must be strict and adjusted to sex and age: a cross-sectional study.

Elisabeth Edvardsen, Erlend Hem, Sigmund A Anderssen

Registry-linked trialAbstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02240836 (Energy Balance and Breast Cancer Aspects-II Study), which is not on this map. Cited by 185 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
185citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02240836 naactive not recruitingnot on this map

Energy Balance and Breast Cancer Aspects-II Study

TypeinterventionalSponsorOslo University HospitalRan2014 to 2027Enrolled545ConditionsDCIS Grade 3, Stage I Breast Cancer, Stage II Breast Cancer, LCIS, Lobular Carcinoma in SituArmsIntervention. Exercise
3 · Its place in the literature

Who cites it

185 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Sex as a moderator of the association between cardiorespiratory fitness and depressive symptoms in older adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
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  4. Comparison of cheese with and withoutJournal of the International Society of Sports Nutrition · 2025
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  12. Effect ofNutrients · 2022
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125 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elisabeth EdvardsenNorwegian School of Sport Sciences, Department of Sports Medicine, Oslo, Norway ; Oslo University Hospital, Ullevål, Department of Pulmonary Medicine, Oslo, Norway.
Erlend HemNorwegian School of Sport Sciences, Department of Sports Medicine, Oslo, Norway.
Sigmund A AnderssenNorwegian School of Sport Sciences, Department of Sports Medicine, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe different end criteria for reaching maximal oxygen uptake (VO2max) during a continuous graded exercise test on the treadmill, and to explore the manner by which different end criteria have an impact on the magnitude of the VO2max result.

methodsA sample of 861 individuals (390 women) aged 20-85 years performed an exercise test on a treadmill until exhaustion. Gas exchange, heart rate, blood lactate concentration and Borg Scale6-20 rating were measured, and the impact of different end criteria on VO2max was studied;VO2 leveling off, maximal heart rate (HRmax), different levels of respiratory exchange ratio (RER), and postexercise blood lactate concentration.

resultsEight hundred and four healthy participants (93%) fulfilled the exercise test until voluntary exhaustion. There were no sex-related differences in HRmax, RER, or Borg Scale rating, whereas blood lactate concentration was 18% lower in women (P<0.001). Forty-two percent of the participants achieved a plateau in VO2; these individuals had 5% higher ventilation (P = 0.033), 4% higher RER (P<0.001), and 5% higher blood lactate concentration (P = 0.047) compared with participants who did not reach a VO2 plateau. When using RER ≥1.15 or blood lactate concentration ≥8.0 mmol•L(-1), VO2max was 4% (P = 0.012) and 10% greater (P<0.001), respectively. A blood lactate concentration ≥8.0 mmol•L(-1) excluded 63% of the participants in the 50-85-year-old cohort.

conclusionsA range of typical end criteria are presented in a random sample of subjects aged 20-85 years. The choice of end criteria will have an impact on the number of the participants as well as the VO2max outcome. Suggestions for new recommendations are given.

Indexed as

Sex CharacteristicsAdultAgedAged, 80 and overAgingBiological TransportCross-Sectional StudiesEndpoint DeterminationExerciseExercise TestFemaleHumansMaleMiddle AgedOxygenYoung AdultOxygen

Identifiers

PMID24454832
PMCPMC3891752

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.