ArticlePloS one2014
Adolescent brain maturation and cortical folding: evidence for reductions in gyrification.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
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Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cortical Gyrification Morphology in Individuals with ASD and ADHD across the Lifespan: A Systematic Review and Meta-Analysis.Cerebral cortex (New York, N.Y. : 1991) · 2021Pooled it
- Effects of Long-term Diving Training on Cortical Gyrification.Scientific reports · 2016Trial
- Interaction Effect of Panic Disorder Diagnosis and Early Trauma History on Cortical Gyrification Patterns.Psychiatry investigation · 2026Article
- Lower Gyrification of the Ventromedial Prefrontal Cortex in Posttraumatic Stress Disorder: An ENIGMA-PTSD Study.Biological psychiatry global open science · 2026Article
- Prefrontal-centered cortical alterations and network dysconnectivity in cocaine use disorder.Frontiers in psychiatry · 2026Article
- Developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophrenia.Developmental cognitive neuroscience · 2025Article
- The multiscale brain structural re-organization that occurs from childhood to adolescence correlates with cortical morphology maturation and functional specialization.PLoS biology · 2025Article
- Anatomical and behavioural correlates of auditory perception in developmental dyslexia.Brain : a journal of neurology · 2025Article
- Characterising the association between posterior parietal metabolite levels and cortical macrostructure in a cohort spanning childhood to adulthood.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Trajectories of working memory and decision making abilities along juvenile development in mice.Frontiers in neuroscience · 2025Article
- Gender Incongruence and Autistic Traits: Cerebral and Behavioral Underpinnings.Archives of sexual behavior · 2024Article
- Reorganization of adolescent prefrontal cortex circuitry is required for mouse cognitive maturation.Neuron · 2024Article
- Preoperative serum cortisone levels are associated with cognition in preschool-aged children with tetralogy of Fallot after corrective surgery: new evidence from human populations and mice.World journal of pediatrics : WJP · 2024Article
- The association between cortical gyrification and sleep in adolescents and young adults.Sleep · 2024Article
- Neuroanatomical and Functional Dissociations between Variably Present Anterior Lateral Prefrontal Sulci.Journal of cognitive neuroscience · 2023Article
- Cortical signature of depressive symptoms in frontotemporal dementia: A surface-based analysis.Annals of clinical and translational neurology · 2023Article
- The association between cortical gyrification and sleep in adolescents and young adults.bioRxiv : the preprint server for biology · 2023Article
- Neuroanatomical and functional dissociations between variably present anterior lateral prefrontal sulci.bioRxiv : the preprint server for biology · 2023Article
- Assessing cortical features in early stage ASD children.Frontiers in psychiatry · 2023Article
- Structural neuroimaging phenotypes and associated molecular and genomic underpinnings in autism: a review.Frontiers in neuroscience · 2023Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
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Abstract
Evidence from anatomical and functional imaging studies have highlighted major modifications of cortical circuits during adolescence. These include reductions of gray matter (GM), increases in the myelination of cortico-cortical connections and changes in the architecture of large-scale cortical networks. It is currently unclear, however, how the ongoing developmental processes impact upon the folding of the cerebral cortex and how changes in gyrification relate to maturation of GM/WM-volume, thickness and surface area. In the current study, we acquired high-resolution (3 Tesla) magnetic resonance imaging (MRI) data from 79 healthy subjects (34 males and 45 females) between the ages of 12 and 23 years and performed whole brain analysis of cortical folding patterns with the gyrification index (GI). In addition to GI-values, we obtained estimates of cortical thickness, surface area, GM and white matter (WM) volume which permitted correlations with changes in gyrification. Our data show pronounced and widespread reductions in GI-values during adolescence in several cortical regions which include precentral, temporal and frontal areas. Decreases in gyrification overlap only partially with changes in the thickness, volume and surface of GM and were characterized overall by a linear developmental trajectory. Our data suggest that the observed reductions in GI-values represent an additional, important modification of the cerebral cortex during late brain maturation which may be related to cognitive development.
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