ArticlePloS one2014
Bat airway epithelial cells: a novel tool for the study of zoonotic viruses.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Chiropteran (Animals : an open access journal from MDPI · 2026Article
- Discovery and characterization of Sager Creek virus, a new orthohantavirus in prairie voles (Microtus ochrogaster).Npj viruses · 2025Article
- Establishment of a cell line from the hematophagous Bat Desmodus rotundus susceptible to Lyssavirus rabies.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Bats as instructive animal models for studying longevity and aging.Annals of the New York Academy of Sciences · 2024Review
- Establishment of immortalized Egyptian Rousettus bat cell lines.FEBS open bio · 2024Article
- Distinct phenotype of SARS-CoV-2 Omicron BA.1 in human primary cells but no increased host range in cell lines of putative mammalian reservoir species.Virus research · 2024Article
- Reduced IFN-ß inhibitory activity of Lagos bat virus phosphoproteins in human compared to Eidolon helvum bat cells.PloS one · 2022Article
- Middle East Respiratory Syndrome Coronavirus (MERS-CoV): State of the Science.Microorganisms · 2020Review
- Novel methods for in vitro modeling of pancreatic cancer reveal important aspects for successful primary cell culture.BMC cancer · 2020Article
- Rousettus aegyptiacus Bats Do Not Support Productive Nipah Virus Replication.The Journal of infectious diseases · 2020Article
- Orthohantavirus Isolated in Reservoir Host Cells Displays Minimal Genetic Changes and Retains Wild-Type Infection Properties.Viruses · 2020Article
- Productive Propagation of Rift Valley Fever Phlebovirus Vaccine Strain MP-12 in Rousettus aegyptiacus Fruit Bats.Viruses · 2018Article
- Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission.Scientific reports · 2018Article
- Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses.Virology journal · 2018Article
- Tools to study pathogen-host interactions in bats.Virus research · 2018Review
- Unexpected Functional Divergence of Bat Influenza Virus NS1 Proteins.Journal of virology · 2018Article
- Mycoplasma ovipneumoniae induces sheep airway epithelial cell apoptosis through an ERK signalling-mediated mitochondria pathway.BMC microbiology · 2016Article
- Epithelial cell lines of the cotton rat (Sigmodon hispidus) are highly susceptible in vitro models to zoonotic Bunya-, Rhabdo-, and Flaviviruses.Virology journal · 2016Article
- Fruits of virus discovery: new pathogens and new experimental models.Journal of virology · 2015Article
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Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bats have been increasingly recognized as reservoir of important zoonotic viruses. However, until now many attempts to isolate bat-borne viruses in cell culture have been unsuccessful. Further, experimental studies on reservoir host species have been limited by the difficulty of rearing these species. The epithelium of the respiratory tract plays a central role during airborne transmission, as it is the first tissue encountered by viral particles. Although several cell lines from bats were established recently, no well-characterized, selectively cultured airway epithelial cells were available so far. Here, primary cells and immortalized cell lines from bats of the two important suborders Yangochiroptera and Yinpterochiroptera, Carollia perspicillata (Seba's short-tailed bat) and Eidolon helvum (Straw-colored fruit bat), were successfully cultured under standardized conditions from both fresh and frozen organ specimens by cell outgrowth of organ explants and by the use of serum-free primary cell culture medium. Cells were immortalized to generate permanent cell lines. Cells were characterized for their epithelial properties such as expression of cytokeratin and tight junctions proteins and permissiveness for viral infection with Rift-Valley fever virus and vesicular stomatitis virus Indiana. These cells can serve as suitable models for the study of bat-borne viruses and complement cell culture models for virus infection in human airway epithelial cells.
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Registered trials
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