Evidence map›Paper›PMID 24454591›Full record

ArticleTrials in vaccinology2013

A neonatal oral

Kara Jensen, Myra Grace Dela Pena, Robert L Wilson, Uma Devi K Ranganathan, William R Jacobs, Glenn Fennelly, Michelle Larsen, Koen K A Van Rompay, Pamela A Kozlowski, Kristina Abel

Open access · hybridAbstract read
In one paragraph

Article in Trials in vaccinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. RecombinantVaccines · 2025
    Review
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  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Kara JensenDepartment of Microbiology and Immunology, and Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, NC, United States.
Myra Grace Dela PenaDepartment of Microbiology and Immunology, and Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, NC, United States.
Robert L WilsonDepartment of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA.
Uma Devi K RanganathanAlbert Einstein College of Medicine, New York, United States.
William R JacobsAlbert Einstein College of Medicine, New York, United States.
Glenn FennellyAlbert Einstein College of Medicine, New York, United States.
Michelle LarsenAlbert Einstein College of Medicine, New York, United States.
Koen K A Van RompayCalifornia National Primate Research Center, University of California at Davis, CA, United States.
Pamela A KozlowskiDepartment of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA.
Kristina AbelDepartment of Microbiology and Immunology, and Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, NC, United States.
Albert Einstein College of Medicine · USLouisiana State University Health Sciences Center New Orleans · USUniversity of California, Davis · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
ZONA PELLUCIDA PEPTIDES AS IMMUNOCONTRACEPTIVE ANTIGENSP51RR000169 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI HYDE, DALLAS MELVIN · 1985 to 2011
$126.2M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Training in Sexually Transmitted Infections and HIVT32AI007001 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SENA-SOBERANO, ARLENE C. · 1985 to 2025
$10.9M
Molecular Biology of Viral Diseases Predoctoral Training GrantT32AI007419 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark T Heise, CARY A MOODY · 1993 to 2026
$4.7M
Optimizing Oral Pediatric HIV Vaccines to Prevent Breast Milk TransmissionR01DE022287 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DE PARIS, KRISTINA · 2012 to 2016
$4.5M
A Novel Oral Combination Pediatric HIV and TB VaccineR01DE019064 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DE PARIS, KRISTINA, FENNELLY, GLENN · 2008 to 2014
$3.3M
NCRR NIH HHS P51 RR000169NIAID NIH HHS P30 AI050410NIAID NIH HHS T32 AI007001NIAID NIH HHS T32 AI007419NIDCR NIH HHS R01 DE019064NIDCR NIH HHS R01 DE022287NIH HHS P51 OD011107
6 · The paper itself

Abstract

Mother-to-child-transmission of HIV by breast-feeding remains a major obstacle in the eradication of HIV infection. Compared to adults, HIV-infected infants have more rapid disease and show higher susceptibility to co-infections like tuberculosis (TB). Although the Bacille Calmette-Guérin vaccine can be administered at birth to protect against TB, BCG can disseminate in HIV-infected infants and increase mortality. Thus, a pediatric combination vaccine to stop both HIV and TB infection in infants is urgently needed. Towards the goal of developing a pediatric combination HIV-TB vaccine to prevent both oral HIV acquisition by breast-feeding and TB infection, we tested and optimized an immunization regimen using a novel live attenuated

Identifiers

PMID24454591
PMCPMC3894789
OpenAlexW2000294633

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.