ArticleBeilstein journal of organic chemistry2014
The regioselective synthesis of spirooxindolo pyrrolidines and pyrrolizidines via three-component reactions of acrylamides and aroylacrylic acids with isatins and α-amino acids.
Article in Beilstein journal of organic chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Decarboxylative 1,3-dipolar cycloadditions of l-proline.RSC advances · 2024Review
- Novel candidates synthesis of indenopyrazole, indenoazine and indenothiophene, with anticancer andFuture medicinal chemistry · 2024Article
- Diversified strategy for the synthesis of DNA-encoded oxindole libraries.Chemical science · 2021Article
- Synthesis, antioxidant and antimicrobial activities of novel thiopyrano[2,3-d]thiazoles based on aroylacrylic acids.Molecular diversity · 2017Article
- Molecular Hybridization-Guided One-Pot Multicomponent Synthesis of Turmerone Motif-Fused 3,3'-Pyrrolidinyl-dispirooxindoles via a 1,3-Dipolar Cycloaddition Reaction.Molecules (Basel, Switzerland) · 2017Article
- Molecular diversity of spirooxindoles. Synthesis and biological activity.Molecular diversity · 2016Review
- Synthesis and Regioselective Reaction of Some Unsymmetrical Heterocyclic Chalcone Derivatives and Spiro Heterocyclic Compounds as Antibacterial Agents.Molecules (Basel, Switzerland) · 2015Article
- Potent Synergy between Spirocyclic Pyrrolidinoindolinones and Fluconazole against Candida albicans.ChemMedChem · 2015Article
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Authors and funding
7 authors.
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Abstract
The regioselective three-component condensation of azomethine ylides derived from isatins and α-amino acids with acrylamides or aroylacrylic acids as dipolarophiles has been realized through a one-pot 1,3-dipolar cycloaddition protocol. Decarboxylation of 2'-aroyl-2-oxo-1,1',2,2',5',6',7',7a'-octahydrospiro[indole-3,3'-pyrrolizine]-1'-carboxylic acids is accompanied by cyclative rearrangement with formation of dihydropyrrolizinyl indolones.
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