Evidence map›Paper›PMID 24454457›Full record

ArticleJournal of breast cancer2013

Case-control study on the fibroblast growth factor receptor 2 gene polymorphisms associated with breast cancer in chinese han women.

Chun-Lian Liu, Xiao-Ping Hu, Wei-Dong Guo, Li Yang, Jie Dang, Hai-Yan Jiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of breast cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Fibroblast growth factor receptor 2 gene (Saudi journal of biological sciences · 2021
    Article
  6. The association of genetic variants inBioscience reports · 2019
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Chun-Lian LiuDepartment of Center for Reproductive Medicine, General Hospital, Ningxia Medical University, Ningxia, China. ; Key Laboratory of Fertility Preservation and Maintenance, Ningxia Medical University, Ministry of Education, Ningxia, China.
Xiao-Ping HuDepartment of Clinical Laboratory, Ningxiang Hospital, Hunan, China.
Wei-Dong GuoDepartment of Surgical Oncology, General Hospital, Ningxia Medical University, Ningxia, China.
Li YangDepartment of Clinical Laboratory, General Hospital, Ningxia Medical University, Ningxia, China.
Jie DangKey Laboratory of Fertility Preservation and Maintenance, Ningxia Medical University, Ministry of Education, Ningxia, China. ; Department of Medical Genetics and Cell Biology, Ningxia Medical University, Ningxia, China.
Hai-Yan JiaoKey Laboratory of Fertility Preservation and Maintenance, Ningxia Medical University, Ministry of Education, Ningxia, China. ; Department of Medical Genetics and Cell Biology, Ningxia Medical University, Ningxia, China.
Ningxia Medical University · CNNingxia Hui Autonomous Region Peoples Hospital · CNNingxia Medical University General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGenetic variation in fibroblast growth factor receptor 2 (FGFR2) is a newly described risk factor for breast cancer. This study aimed to evaluate the association of four single nucleotide polymorphisms (SNPs) in FGFR2 with breast cancer in Han Chinese women.

methodsTwo hundred three women with breast cancer and 200 breast cancer-free age-matched controls were selected. Four SNPs (rs2981579, rs1219648, rs2420946, and rs2981582) and their haplotypes were analyzed to test for their association with breast cancer susceptibility. The presence of the four FGFR2 SNPs was determined by polymerase chain reaction-restriction fragment length polymorphism analysis.

resultsA statistically significant difference was observed in the frequency of rs2981582 in the FGFR2 gene (p<0.05) between case and control groups. In subjects stratified by menopausal status, rs2981582 TT, rs2420946 AA, and rs1219648 CC were significantly associated with the risk of breast cancer in postmenopausal subjects, but no significant associations between these four SNPs and the risk of breast cancer were identified in premenopausal subjects. Further, there was no significant association between hormone receptor status (estrogen receptor and progesterone receptor) and breast cancer risk. Six common (> 3%) haplotypes were identified. Three of these haplotypes, CGTC (odds ratio [OR], 0.613; 95% confidence interval [CI], 0.457-0.82; p=0.001), TGTC (OR, 6.561; 95% CI, 2.064-20.854; p<0.001), and CATC (OR, 12.645; 95% CI, 1.742-91.799; p=0.001) were significantly associated with breast cancer risk.

conclusionOur findings indicated that the SNP rs2981582 and haplotypes CGTC, TGTC, and CATC in FGFR2 may be associated with an increased risk of breast cancer in Han Chinese women.

Indexed as

Breast neoplasmsSingle nucleotide polymorphismsType 2 fibroblast growth factor receptor

Identifiers

PMID24454457
PMCPMC3893337
OpenAlexW2062034310

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.